| Chapter title |
Application of Nuclear Magnetic Resonance and Hybrid Methods to Structure Determination of Complex Systems.
|
|---|---|
| Chapter number | 22 |
| Book title |
Advanced Technologies for Protein Complex Production and Characterization
|
| Published in |
Advances in experimental medicine and biology, May 2016
|
| DOI | 10.1007/978-3-319-27216-0_22 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-927214-6, 978-3-31-927216-0
|
| Authors |
Filippo Prischi, Annalisa Pastore, Prischi, Filippo, Pastore, Annalisa |
| Editors |
M. Cristina Vega |
| Abstract |
The current main challenge of Structural Biology is to undertake the structure determination of increasingly complex systems in the attempt to better understand their biological function. As systems become more challenging, however, there is an increasing demand for the parallel use of more than one independent technique to allow pushing the frontiers of structure determination and, at the same time, obtaining independent structural validation. The combination of different Structural Biology methods has been named hybrid approaches. The aim of this review is to critically discuss the most recent examples and new developments that have allowed structure determination or experimentally-based modelling of various molecular complexes selecting them among those that combine the use of nuclear magnetic resonance and small angle scattering techniques. We provide a selective but focused account of some of the most exciting recent approaches and discuss their possible further developments. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 27% |
| Student > Bachelor | 2 | 18% |
| Professor | 1 | 9% |
| Lecturer | 1 | 9% |
| Student > Master | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 2 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 45% |
| Agricultural and Biological Sciences | 2 | 18% |
| Chemistry | 1 | 9% |
| Medicine and Dentistry | 1 | 9% |
| Unknown | 2 | 18% |