Chapter title |
Oxygen Transport to Tissue XXXVIII
|
---|---|
Chapter number | 23 |
Book title |
Oxygen Transport to Tissue XXXVIII
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-38810-6_23 |
Pubmed ID | |
Book ISBNs |
978-3-31-938808-3, 978-3-31-938810-6
|
Authors |
Semyachkina-Glushkovskaya, Oxana, Borisova, Ekaterina, Namikin, Anton, Fedosov, Ivan, Abdurashitov, Arkady, Zhinchenko, Ekaterina, Gekalyuk, Artem, Ulanova, Maria, Rezunbaeva, Victoria, Avramov, Latchezar, Zhu, Dan, Luo, Qingming, Tuchin, Valery, Oxana Semyachkina-Glushkovskaya, Ekaterina Borisova, Anton Namikin, Ivan Fedosov, Arkady Abdurashitov, Ekaterina Zhinchenko, Artem Gekalyuk, Maria Ulanova, Victoria Rezunbaeva, Latchezar Avramov, Dan Zhu, Qingming Luo, Valery Tuchin |
Editors |
Qingming Luo, Lin Z. Li, David K. Harrison, Hua Shi, Duane F. Bruley |
Abstract |
We studied the level of blood oxygen saturation (SpO2) in the brain in newborn rats in the pre- and post-stroke periods, as well as the changes in cerebral blood flow and beta-arrestin-1 as a marker of hypoxic stress. Our results show that mild hypoxia precedes the stroke development and is associated with venous relaxation and decrease blood outflow from the brain resulting in the elevation of synthesis of beta-arrestin-1 in the brain. The incidence of stroke is characterized by severe hypoxia, which is accompanied by the progression of pathological changes in cerebral veins and the high level of beta-arrestin-1. |
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