Chapter title |
Magnetization Transfer MRI Contrast May Correlate with Tissue Redox State in Prostate Cancer.
|
---|---|
Chapter number | 52 |
Book title |
Oxygen Transport to Tissue XXXVIII
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-38810-6_52 |
Pubmed ID | |
Book ISBNs |
978-3-31-938808-3, 978-3-31-938810-6
|
Authors |
Rongwen Tain, He N. Xu, Xiaohong J. Zhou, Lin Z. Li, Kejia Cai |
Editors |
Qingming Luo, Lin Z. Li, David K. Harrison, Hua Shi, Duane F. Bruley |
Abstract |
Developing imaging biomarkers for non-invasive measurement of the tissue redox state is a key research area. Recently, we presented the first non-invasive MR imaging method that demonstrated the correlation between the endogenous chemical exchange saturation transfer (CEST) contrast and the tissue redox state. It is well known that the broadband magnetization transfer (MT) can occur via chemical exchange (CEST) and/or dipole-dipole interactions. The present study investigated if the broadband MT also correlated with the tissue redox state. The preliminary result for the prostate tumor xenografts indeed showed a significant correlation between the broadband MT contrast and the NADH redox ratio quantified with the optical redox scanning. In vivo MT contrast, once calibrated, may potentially serve as an imaging biomarker for tissue redox state. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 18% |
Student > Master | 2 | 18% |
Professor | 1 | 9% |
Researcher | 1 | 9% |
Student > Postgraduate | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 2 | 18% |
Computer Science | 1 | 9% |
Agricultural and Biological Sciences | 1 | 9% |
Neuroscience | 1 | 9% |
Medicine and Dentistry | 1 | 9% |
Other | 0 | 0% |
Unknown | 5 | 45% |