Chapter title |
Oxygen Transport to Tissue XXXVIII
|
---|---|
Chapter number | 6 |
Book title |
Oxygen Transport to Tissue XXXVIII
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-38810-6_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-938808-3, 978-3-31-938810-6
|
Authors |
Shea, Ryan, Smith, Casey, Pias, Sally C, Ryan Shea, Casey Smith, Sally C. Pias, Pias, Sally C. |
Editors |
Qingming Luo, Lin Z. Li, David K. Harrison, Hua Shi, Duane F. Bruley |
Abstract |
High cellular membrane cholesterol is known to generate membrane resistance and reduce oxygen (O2) permeability. As such, cholesterol may contribute to the Warburg effect in tumor cells by stimulating intracellular hypoxia that cannot be detected from extracellular oxygen measurements. We probe the tissue-level impact of the phenomenon, asking whether layering of cells can magnify the influence of cholesterol, to modulate hypoxia in relation to capillary proximity. Using molecular dynamics simulations, we affirm that minimally hydrated, adjacent lipid bilayers have independent physical behavior. Combining this insight with published experimental data, we predict linearly increasing impact of membrane cholesterol on oxygen flux across cells layered in tissue. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 1 | 20% |
Professor > Associate Professor | 1 | 20% |
Student > Doctoral Student | 1 | 20% |
Student > Master | 1 | 20% |
Unknown | 1 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 2 | 40% |
Agricultural and Biological Sciences | 1 | 20% |
Medicine and Dentistry | 1 | 20% |
Unknown | 1 | 20% |