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Epstein Barr Virus

Overview of attention for book
Cover of 'Epstein Barr Virus'

Table of Contents

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    Book Overview
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    Chapter 1 Current Trends and Alternative Scenarios in EBV Research.
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    Chapter 2 Epstein-Barr Virus: Clinical Diagnostics.
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    Chapter 3 Establishment of EBV-Infected Lymphoblastoid Cell Lines.
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    Chapter 4 Generation and Infection of Organotypic Cultures with Epstein-Barr Virus.
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    Chapter 5 Affinity Purification-Mass Spectroscopy Methods for Identifying Epstein-Barr Virus-Host Interactions.
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    Chapter 6 The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma.
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    Chapter 7 Analysis of EBV Transcription Using High-Throughput RNA Sequencing.
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    Chapter 8 Analysis of Viral Promoter Usage in EBV-Infected Cell Lines: A Comparison of qPCR Following Conventional RNA Isolation and Nuclear Run-On Assay.
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    Chapter 9 Analysis of Viral and Cellular MicroRNAs in EBV-Infected Cells.
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    Chapter 10 Isolation and Characterization of Exosomes Released by EBV-Immortalized Cells.
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    Chapter 11 Functional Analysis of Exosomes Derived from EBV-Infected Cells.
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    Chapter 12 Terminal Repeat Analysis of EBV Genomes.
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    Chapter 13 Characterization of EBV Promoters and Coding Regions by Sequencing PCR-Amplified DNA Fragments.
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    Chapter 14 The Use of Chromatin Precipitation Coupled to DNA Sequencing (ChIP-Seq) for the Analysis of Zta Binding to the Human and EBV Genome.
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    Chapter 15 Analysis of Viral Epigenotypes Using Bisulfite Sequencing: A Detailed Protocol for the Crucial Bisulfite Modification and PCR Amplification Steps.
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    Chapter 16 Analysis of Viral Epigenotypes Using Chromatin Immunoprecipitation.
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    Chapter 17 Mice with Reconstituted Human Immune System Components as a Tool to Study Immune Cell Interactions in EBV Infection.
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    Chapter 18 Generation and Analysis of Humanized Mouse Model of EBV Infection.
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    Chapter 19 EBV-Directed T Cell Therapeutics for EBV-Associated Lymphomas.
Attention for Chapter 6: The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma.
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Chapter title
The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma.
Chapter number 6
Book title
Epstein Barr Virus
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6655-4_6
Pubmed ID
27873269
Book ISBNs
978-1-4939-6653-0, 978-1-4939-6655-4
Authors

Hans Knecht M.D., Sabine Mai, Hans Knecht

Editors

Janos Minarovits, Hans Helmut Niller

Abstract

The 3D nuclear architecture is closely related to cellular functions and chromosomes are organized in distinct territories. Quantitative 3D telomere FISH analysis (3D Q-FISH) and 3D super-resolution imaging (3D-SIM) at a resolution up to 80 nm as well as the recently developed combined quantitative 3D TRF2-telomere immune FISH technique (3D TRF2/Telo-Q-FISH) have substantially contributed to elucidate molecular pathogenic mechanisms of hematological diseases. Here we report the methods we applied to uncover major molecular steps involved in the pathogenesis of EBV-associated Hodgkin's lymphoma. These methods allowed us to identify the EBV-encoded oncoprotein LMP1 as a key element in the formation of Hodgkin (H-cell) and multinucleated Reed-Sternberg cells (RS-cell), the diagnostic tumor cell of classical Hodgkin's lymphoma (cHL). LMP1 mediates multinuclearity through downregulation of shelterin proteins, in particular telomere repeat binding factor 2 (TRF2).

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Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 33%
Student > Master 2 22%
Student > Bachelor 1 11%
Lecturer 1 11%
Student > Doctoral Student 1 11%
Other 1 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 33%
Medicine and Dentistry 3 33%
Agricultural and Biological Sciences 2 22%
Unspecified 1 11%

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