| Chapter title |
Glucocorticoids and Metabolic Control.
|
|---|---|
| Chapter number | 1 |
| Book title |
Metabolic Control
|
| Published in |
Handbook of experimental pharmacology, January 2015
|
| DOI | 10.1007/164_2015_1 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-929804-7, 978-3-31-929806-1
|
| Authors |
Lilia Magomedova, Carolyn L. Cummins, Magomedova, Lilia, Cummins, Carolyn L. |
| Editors |
Stephan Herzig |
| Abstract |
In response to stress, the central nervous system initiates a signaling cascade, which leads to the production of glucocorticoids (GCs). GCs act through the glucocorticoid receptor (GR) to coordinate the appropriate cellular response with the primary goal of mobilizing the storage forms of carbon precursors to generate a continuous glucose supply for the brain. Although GCs are critical for maintaining energy homeostasis, excessive GC stimulation leads to a number of undesirable side effects, including hyperglycemia, insulin resistance, fatty liver, obesity, and muscle wasting leading to severe metabolic dysfunction. Summarized below are the diverse metabolic roles of glucocorticoids in energy homeostasis and dysregulation, focusing specifically on glucose, lipid, and protein metabolism. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 85 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 18% |
| Student > Bachelor | 12 | 14% |
| Researcher | 8 | 9% |
| Student > Master | 6 | 7% |
| Student > Postgraduate | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 28 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 16% |
| Biochemistry, Genetics and Molecular Biology | 14 | 16% |
| Agricultural and Biological Sciences | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Neuroscience | 5 | 6% |
| Other | 6 | 7% |
| Unknown | 31 | 36% |