| Chapter title |
Nuclear Receptor Coregulators in Metabolism and Disease.
|
|---|---|
| Chapter number | 5 |
| Book title |
Metabolic Control
|
| Published in |
Handbook of experimental pharmacology, April 2015
|
| DOI | 10.1007/164_2015_5 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-929804-7, 978-3-31-929806-1
|
| Authors |
Giudici, Marco, Goni, Saioa, Fan, Rongrong, Treuter, Eckardt, Marco Giudici, Saioa Goni, Rongrong Fan, Eckardt Treuter |
| Editors |
Stephan Herzig |
| Abstract |
Within the past two decades, coregulators have emerged as essential chromatin components of metabolic signaling by nuclear receptors and additional metabolite-sensing transcription factors. Intriguingly, coregulators themselves are efficient sensors and effectors of metabolic stimuli that modulate gene expression at different levels, often via post-translational modifications of histones or other factors. There is already evidence that alterations of expression or function of coregulators contributes to metabolic disease by propagating disease-specific epigenomes linked to the dysregulation of transcription and downstream pathways. In this chapter we review the current progress made in understanding the role of coregulators in metabolic pathways, with a particular emphasis on their study in vivo and in the context of metabolic disease. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Luxembourg | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 30% |
| Student > Bachelor | 3 | 15% |
| Professor | 2 | 10% |
| Student > Doctoral Student | 1 | 5% |
| Researcher | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 6 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 30% |
| Biochemistry, Genetics and Molecular Biology | 4 | 20% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Computer Science | 1 | 5% |
| Medicine and Dentistry | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 6 | 30% |