| Chapter title |
Role of the cAMP Pathway in Glucose and Lipid Metabolism.
|
|---|---|
| Chapter number | 32 |
| Book title |
Metabolic Control
|
| Published in |
Handbook of experimental pharmacology, January 2015
|
| DOI | 10.1007/164_2015_32 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-929804-7, 978-3-31-929806-1
|
| Authors |
Kim Ravnskjaer, Anila Madiraju, Marc Montminy, Ravnskjaer, Kim, Madiraju, Anila, Montminy, Marc |
| Editors |
Stephan Herzig |
| Abstract |
3'-5'-Cyclic adenosine monophosphate (cyclic AMP or cAMP) was first described in 1957 as an intracellular second messenger mediating the effects of glucagon and epinephrine on hepatic glycogenolysis (Berthet et al., J Biol Chem 224(1):463-475, 1957). Since this initial characterization, cAMP has been firmly established as a versatile molecular signal involved in both central and peripheral regulation of energy homeostasis and nutrient partitioning. Many of these effects appear to be mediated at the transcriptional level, in part through the activation of the transcription factor CREB and its coactivators. Here we review current understanding of the mechanisms by which the cAMP signaling pathway triggers metabolic programs in insulin-responsive tissues. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 19% |
| Student > Ph. D. Student | 15 | 19% |
| Student > Doctoral Student | 7 | 9% |
| Researcher | 7 | 9% |
| Student > Master | 7 | 9% |
| Other | 5 | 6% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 30% |
| Agricultural and Biological Sciences | 11 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Medicine and Dentistry | 4 | 5% |
| Immunology and Microbiology | 2 | 3% |
| Other | 8 | 10% |
| Unknown | 24 | 31% |