Chapter title |
Bioinformatics Based Approaches to Study Virus–Host Interactions During Chikungunya Virus Infection
|
---|---|
Chapter number | 17 |
Book title |
Chikungunya Virus
|
Published in |
Methods in molecular biology, May 2016
|
DOI | 10.1007/978-1-4939-3618-2_17 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3616-8, 978-1-4939-3618-2
|
Authors |
Sreejith Rajasekharan, Sanjay Gupta |
Editors |
Justin Jang Hann Chu, Swee Kim Ang |
Abstract |
The limitations of high-throughput genomic methods used for studying virus-host interactions make it difficult to directly obtain insights on virus pathogenesis. In this chapter, the central steps of a protein structure similarity based computational approach used to predict the host interactors of Chikungunya virus are explained by highlighting the important aspects that need to be considered. Identification of such conserved set of putative interactions that allow the virus to take control of the host has the potential to deepen our understanding of the virus-specific remodeling processes of the host cell and illuminate new arenas of disease intervention. |
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