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Bioinformatics in MicroRNA Research

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Cover of 'Bioinformatics in MicroRNA Research'

Table of Contents

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    Book Overview
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    Chapter 1 MicroRNAs, Long Noncoding RNAs, and Their Functions in Human Disease
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    Chapter 2 MicroRNA Expression: Protein Participants in MicroRNA Regulation
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    Chapter 3 Viral MicroRNAs, Host MicroRNAs Regulating Viruses, and Bacterial MicroRNA-Like RNAs
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    Chapter 4 MicroRNAs: Biomarkers, Diagnostics, and Therapeutics
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    Chapter 5 Relational Databases and Biomedical Big Data
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    Chapter 6 Semantic Technologies and Bio-Ontologies
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    Chapter 7 Genome-Wide Analysis of MicroRNA-Regulated Transcripts
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    Chapter 8 Computational Prediction of MicroRNA Target Genes, Target Prediction Databases, and Web Resources
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    Chapter 9 Exploring MicroRNA::Target Regulatory Interactions by Computing Technologies
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    Chapter 10 The Limitations of Existing Approaches in Improving MicroRNA Target Prediction Accuracy.
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    Chapter 11 Genomic Regulation of MicroRNA Expression in Disease Development
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    Chapter 12 Next-Generation Sequencing for MicroRNA Expression Profile
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    Chapter 13 Handling High-Dimension (High-Feature) MicroRNA Data.
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    Chapter 14 Effective Removal of Noisy Data Via Batch Effect Processing
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    Chapter 15 Logical Reasoning (Inferencing) on MicroRNA Data
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    Chapter 16 Machine Learning Techniques in Exploring MicroRNA Gene Discovery, Targets, and Functions
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    Chapter 17 Involvement of MicroRNAs in Diabetes and Its Complications
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    Chapter 18 MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role.
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    Chapter 19 Expression of MicroRNAs in Thyroid Carcinoma.
Attention for Chapter 17: Involvement of MicroRNAs in Diabetes and Its Complications
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Chapter title
Involvement of MicroRNAs in Diabetes and Its Complications
Chapter number 17
Book title
Bioinformatics in MicroRNA Research
Published in
Methods in molecular biology, May 2017
DOI 10.1007/978-1-4939-7046-9_17
Pubmed ID
Book ISBNs
978-1-4939-7044-5, 978-1-4939-7046-9
Authors

Bin Wu M.D., Ph.D., Daniel Miller, Bin Wu

Editors

Jingshan Huang, Glen M. Borchert, Dejing Dou, Jun (Luke) Huan, Wenjun Lan, Ming Tan, Bin Wu

Abstract

Diabetes is a severe condition worldwide. It is characterized by chronic hyperglycemia and is caused by defects in insulin production, secretion, and action. Both genetic and environmental factors contribute to the development of type 1 and type 2 diabetes. The pathogenesis of diabetes is complex and the underlying molecular mechanisms are only partially understood. MicroRNAs (miRNAs) play a fundamental role in diabetes and its complications. This chapter focuses on the dysregulation of miRNAs involved in the regulation of pancreatic islet insulin production and secretion as well as action and signaling in peripheral tissues. The roles of miRNAs in the development of diabetic complications are also discussed. Modulating miRNA expression, by either upregulation or inhibition, holds a promise as a strategy for treating this metabolic disease.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 22%
Student > Ph. D. Student 2 22%
Student > Bachelor 1 11%
Other 1 11%
Librarian 1 11%
Other 0 0%
Unknown 2 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 22%
Nursing and Health Professions 1 11%
Chemical Engineering 1 11%
Agricultural and Biological Sciences 1 11%
Medicine and Dentistry 1 11%
Other 0 0%
Unknown 3 33%