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Transient Receptor Potential Canonical Channels and Brain Diseases

Overview of attention for book
Cover of 'Transient Receptor Potential Canonical Channels and Brain Diseases'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 TRP Channel Classification
  3. Altmetric Badge
    Chapter 2 TRPC Channel Structure and Properties
  4. Altmetric Badge
    Chapter 3 TRPC Channel Downstream Signaling Cascades
  5. Altmetric Badge
    Chapter 4 TRPC Channels in Health and Disease
  6. Altmetric Badge
    Chapter 5 TRPC Channels and Programmed Cell Death
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    Chapter 6 TRPC Channels and Stroke
  8. Altmetric Badge
    Chapter 7 TRPC Channels and Alzheimer’s Disease
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    Chapter 8 TRPC Channels and Parkinson’s Disease
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    Chapter 9 TRPC Channels and Neuron Development, Plasticity, and Activities
  11. Altmetric Badge
    Chapter 10 TRPC Channels and Brain Inflammation
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    Chapter 11 TRPC Channels and Epilepsy
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    Chapter 12 TRPC Channels and Mental Disorders
  14. Altmetric Badge
    Chapter 13 TRPC Channels and Cell Proliferation
  15. Altmetric Badge
    Chapter 14 TRPC Channels and Glioma
Attention for Chapter 11: TRPC Channels and Epilepsy
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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Chapter title
TRPC Channels and Epilepsy
Chapter number 11
Book title
Transient Receptor Potential Canonical Channels and Brain Diseases
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-94-024-1088-4_11
Pubmed ID
28508318
Book ISBNs
978-9-40-241086-0, 978-9-40-241088-4, 978-9-40-241086-0, 978-9-40-241088-4
Authors

Fang Zheng, Zheng, Fang

Abstract

Accumulating evidence suggest that TRPC channels play critical roles in various aspects of epileptogenesis. TRPC1/4 channels are major contributors to nonsynaptically derived epileptiform burst firing in the CA1 and the lateral septum. TRPC7 channels play a critical role in synaptically derived epileptiform burst firing. The reduction of spontaneous epileptiform bursting in the CA3 is correlated to a reduction in pilocarpine-induced SE in vivo in TRPC7 knockout mice. TRPC channels are also significant contributors to SE-induced neuronal cell death. Although the pilocarpine-induced SE itself is not significantly reduced, the SE-induced neuronal cell death is significantly reduced in the CA1 and the lateral septum, indicating that TRPC1/4 channels directly contribute to SE-induced neuronal cell death. Genetic ablation of TRPC5 also reduces SE-induced neuronal cell death in the CA1 and CA3 areas of the hippocampus.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 27%
Student > Master 2 18%
Student > Doctoral Student 1 9%
Librarian 1 9%
Student > Ph. D. Student 1 9%
Other 1 9%
Unknown 2 18%
Readers by discipline Count As %
Medicine and Dentistry 3 27%
Biochemistry, Genetics and Molecular Biology 3 27%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Nursing and Health Professions 1 9%
Neuroscience 1 9%
Other 0 0%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 May 2017.
All research outputs
#13,552,541
of 22,971,207 outputs
Outputs from Advances in experimental medicine and biology
#1,901
of 4,957 outputs
Outputs of similar age
#212,659
of 421,094 outputs
Outputs of similar age from Advances in experimental medicine and biology
#171
of 490 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,957 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,094 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 490 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.

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