| Chapter title |
TRPC Channels and Parkinson’s Disease
|
|---|---|
| Chapter number | 8 |
| Book title |
Transient Receptor Potential Canonical Channels and Brain Diseases
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-94-024-1088-4_8 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-241086-0, 978-9-40-241088-4, 978-9-40-241086-0, 978-9-40-241088-4
|
| Authors |
Pramod Sukumaran, Yuyang Sun, Anne Schaar, Senthil Selvaraj, Brij B. Singh, Sukumaran, Pramod, Sun, Yuyang, Schaar, Anne, Selvaraj, Senthil, Singh, Brij B. |
| Abstract |
Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson's disease; however, almost all of them are directly or indirectly dependent on Ca(2+) signaling. Importantly, though disturbances in Ca(2+) homeostasis have been implicated in Parkinson's disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identified as a new class of Ca(2+) channels, and it could be anticipated that these channels could play important roles in neurodegenerative diseases, especially in PD. Thus, in this chapter we have entirely focused on TRPC channels and elucidated its role in PD. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 18% |
| Student > Bachelor | 3 | 14% |
| Student > Ph. D. Student | 3 | 14% |
| Professor | 2 | 9% |
| Other | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 7 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 27% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Nursing and Health Professions | 2 | 9% |
| Medicine and Dentistry | 2 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 8 | 36% |