Chapter title |
TRPC Channel Structure and Properties
|
---|---|
Chapter number | 2 |
Book title |
Transient Receptor Potential Canonical Channels and Brain Diseases
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1088-4_2 |
Pubmed ID | |
Book ISBNs |
978-9-40-241086-0, 978-9-40-241088-4
|
Authors |
Shengjie Feng, Feng, Shengjie |
Abstract |
TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca(2+) concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca(2+). The properties and the functional domains of TRPC channels have been identified by electrophysiological and biochemical methods. However, due to the large size, instability, and flexibility of their complexes, the structures of the members in TRPC family remain unrevealed. More efforts should be made on structure analysis and generating good tools, including specific antibodies, agonist, and antagonist. |
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Demographic breakdown
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Student > Doctoral Student | 2 | 17% |
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Professor | 1 | 8% |
Unknown | 2 | 17% |
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Other | 2 | 17% |
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