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Personalised Medicine

Overview of attention for book
Attention for Chapter 6: RNA Nuclear Export: From Neurological Disorders to Cancer
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Mentioned by

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2 tweeters

Citations

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3 Dimensions

Readers on

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34 Mendeley
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Chapter title
RNA Nuclear Export: From Neurological Disorders to Cancer
Chapter number 6
Book title
Personalised Medicine
Published in
Advances in experimental medicine and biology, August 2017
DOI 10.1007/978-3-319-60733-7_6
Pubmed ID
Book ISBNs
978-3-31-960731-3, 978-3-31-960733-7
Authors

Hautbergue, Guillaume M., Guillaume M. Hautbergue

Abstract

The presence of a nuclear envelope, also known as nuclear membrane, defines the structural framework of all eukaryotic cells by separating the nucleus, which contains the genetic material, from the cytoplasm where the synthesis of proteins takes place. Translation of proteins in Eukaryotes is thus dependent on the active transport of DNA-encoded RNA molecules through pores embedded within the nuclear membrane. Several mechanisms are involved in this process generally referred to as RNA nuclear export or nucleocytoplasmic transport of RNA. The regulated expression of genes requires the nuclear export of protein-coding messenger RNA molecules (mRNAs) as well as non-coding RNAs (ncRNAs) together with proteins and pre-assembled ribosomal subunits. The nuclear export of mRNAs is intrinsically linked to the co-transcriptional processing of nascent transcripts synthesized by the RNA polymerase II. This functional coupling is essential for the survival of cells allowing for timely nuclear export of fully processed transcripts, which could otherwise cause the translation of abnormal proteins such as the polymeric repeat proteins produced in some neurodegenerative diseases. Alterations of the mRNA nuclear export pathways can also lead to genome instability and to various forms of cancer. This chapter will describe the molecular mechanisms driving the nuclear export of RNAs with a particular emphasis on mRNAs. It will also review their known alterations in neurological disorders and cancer, and the recent opportunities they offer for the potential development of novel therapeutic strategies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 24%
Student > Ph. D. Student 6 18%
Researcher 5 15%
Student > Master 4 12%
Lecturer 2 6%
Other 7 21%
Unknown 2 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 50%
Agricultural and Biological Sciences 8 24%
Neuroscience 2 6%
Medicine and Dentistry 2 6%
Physics and Astronomy 1 3%
Other 1 3%
Unknown 3 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2018.
All research outputs
#9,839,931
of 12,846,518 outputs
Outputs from Advances in experimental medicine and biology
#1,703
of 3,218 outputs
Outputs of similar age
#177,821
of 264,386 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 3 outputs
Altmetric has tracked 12,846,518 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,218 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,386 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.