Chapter title |
Role of Protein Linked DNA Breaks in Cancer
|
---|---|
Chapter number | 3 |
Book title |
Personalised Medicine
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-60733-7_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-960731-3, 978-3-31-960733-7
|
Authors |
Walaa R. Allam, Mohamed E. Ashour, Amr A. Waly, Sherif El-Khamisy |
Abstract |
Topoisomerases are a group of specialized enzymes that function to maintain DNA topology by introducing transient DNA breaks during transcription and replication. As a result of abortive topoisomerases activity, topoisomerases catalytic intermediates may be trapped on the DNA forming topoisomerase cleavage complexes (Topcc). Topoisomerases trapping on the DNA is the mode of action of several anticancer drugs, it lead to formation of protein linked DAN breaks (PDBs). PDBs are now considered as one of the most dangerous forms of endogenous DNA damage and a major threat to genomic stability. The repair of PDBs involves both the sensing and repair pathways. Unsuccessful repair of PDBs leads to different signs of genomic instabilities such as chromosomal rearrangements and cancer predisposition. In this chapter we will summarize the role of topoisomerases induced PDBs, identification and signaling, repair, role in transcription. We will also discuss the role of PDBs in cancer with a special focus on prostate cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 25% |
Researcher | 2 | 17% |
Student > Bachelor | 1 | 8% |
Other | 1 | 8% |
Student > Master | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 42% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Nursing and Health Professions | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Unknown | 4 | 33% |