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Personalised Medicine

Overview of attention for book
Attention for Chapter 3: Role of Protein Linked DNA Breaks in Cancer
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Chapter title
Role of Protein Linked DNA Breaks in Cancer
Chapter number 3
Book title
Personalised Medicine
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-3-319-60733-7_3
Pubmed ID
Book ISBNs
978-3-31-960731-3, 978-3-31-960733-7

Walaa R. Allam, Mohamed E. Ashour, Amr A. Waly, Sherif El-Khamisy


Topoisomerases are a group of specialized enzymes that function to maintain DNA topology by introducing transient DNA breaks during transcription and replication. As a result of abortive topoisomerases activity, topoisomerases catalytic intermediates may be trapped on the DNA forming topoisomerase cleavage complexes (Topcc). Topoisomerases trapping on the DNA is the mode of action of several anticancer drugs, it lead to formation of protein linked DAN breaks (PDBs). PDBs are now considered as one of the most dangerous forms of endogenous DNA damage and a major threat to genomic stability. The repair of PDBs involves both the sensing and repair pathways. Unsuccessful repair of PDBs leads to different signs of genomic instabilities such as chromosomal rearrangements and cancer predisposition. In this chapter we will summarize the role of topoisomerases induced PDBs, identification and signaling, repair, role in transcription. We will also discuss the role of PDBs in cancer with a special focus on prostate cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 17%
Researcher 1 17%
Other 1 17%
Student > Doctoral Student 1 17%
Unknown 2 33%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Social Sciences 1 17%
Unknown 3 50%