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Personalised Medicine

Overview of attention for book
Attention for Chapter 1: Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)

Mentioned by

twitter
7 tweeters
googleplus
1 Google+ user

Citations

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3 Dimensions

Readers on

mendeley
14 Mendeley
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Chapter title
Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair
Chapter number 1
Book title
Personalised Medicine
Published in
Advances in experimental medicine and biology, August 2017
DOI 10.1007/978-3-319-60733-7_1
Pubmed ID
Book ISBNs
978-3-31-960731-3, 978-3-31-960733-7
Authors

Williams, Dean T., Staples, Christopher J., Dean T. Williams, Christopher J. Staples

Abstract

Genome stability is maintained by a number of elegant mechanisms, which sense and repair damaged DNA. Germline defects that compromise genomic integrity result in cancer predisposition, exemplified by rare syndromes caused by mutations in certain DNA repair genes. These individuals often exhibit other symptoms including progeria and neurodegeneration. Paradoxically, some of these deleterious genetic alterations provide novel therapeutic opportunities to target cancer cells; an excellent example of such an approach being the recent development of poly (ADP-ribose) polymerase inhibitors as the first 'synthetic lethal' medicine for patients with BRCA-mutant cancers. The therapeutic exploitation of synthetic lethal interactions has enabled a novel approach to personalised medicine based on continued molecular profiling of patient and tumour material. This profiling may also aid clinicians in the identification of specific drug resistance mechanisms following relapse, and enable appropriate modification of the therapeutic regimen. This chapter focuses on therapeutic strategies designed to target aspects of the DNA damage response, and examines emerging themes demonstrating mechanistic overlap between DNA repair and neurodegeneration.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 21%
Other 2 14%
Student > Bachelor 2 14%
Unspecified 1 7%
Student > Ph. D. Student 1 7%
Other 1 7%
Unknown 4 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 29%
Pharmacology, Toxicology and Pharmaceutical Science 2 14%
Computer Science 2 14%
Unspecified 1 7%
Agricultural and Biological Sciences 1 7%
Other 1 7%
Unknown 3 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2017.
All research outputs
#4,399,886
of 16,523,825 outputs
Outputs from Advances in experimental medicine and biology
#614
of 3,748 outputs
Outputs of similar age
#82,589
of 275,119 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 3 outputs
Altmetric has tracked 16,523,825 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 3,748 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,119 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.