Chapter title |
Regulatory B Cells in Experimental Autoimmune Encephalomyelitis (EAE).
|
---|---|
Chapter number | 17 |
Book title |
Regulatory B Cells
|
Published in |
Methods in molecular biology, July 2014
|
DOI | 10.1007/978-1-4939-1161-5_17 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1160-8, 978-1-4939-1161-5
|
Authors |
Ray A, Basu S, Avijit Ray, Sreemanti Basu |
Abstract |
B cells are thought to play a pathogenic role in multiple sclerosis (MS), an autoimmune disease affecting the central nervous system (CNS). This idea is supported by the reduction of disease in MS patients undergoing antibody-mediated B cell depletion therapy. In contrast, in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, B cells have been shown to play a regulatory role. This is suggestive of a dual role for B cells in CNS autoimmunity. It is possible that a critical balance between the pathogenic and regulatory populations of B cells might be involved in the manifestation of the disease. Although in mice, different B cell subsets have been shown to exert immunoregulation through varied mechanisms, the phenotype of regulatory B cells in humans and factors affecting their function are not well known. Also, the origin and development of regulatory B cells is not known. It is important to thoroughly identify the different populations of B cells that might be involved in suppressing CNS autoimmunity, their mode of function and factors that regulate their immunosuppressive properties for using regulatory B cells as a therapy for MS. Here we present methods to study the phenotype and mechanisms of immune suppression by B cells in different mouse models of EAE. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 9% |
Unknown | 10 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 2 | 18% |
Student > Postgraduate | 2 | 18% |
Other | 1 | 9% |
Lecturer | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Other | 3 | 27% |
Unknown | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 27% |
Agricultural and Biological Sciences | 3 | 27% |
Unspecified | 1 | 9% |
Energy | 1 | 9% |
Immunology and Microbiology | 1 | 9% |
Other | 0 | 0% |
Unknown | 2 | 18% |