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Regulatory B Cells

Overview of attention for book
Cover of 'Regulatory B Cells'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Purification and Immunophenotypic Characterization of Murine MZ and T2-MZP Cells
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    Chapter 2 Purification and Immune Phenotyping of B-1 Cells from Body Cavities of Mice
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    Chapter 3 Purification and Immunophenotypic Characterization of Murine B10 B Cells
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    Chapter 4 Purification and Immunophenotypic Characterization of Human B Cells with Regulatory Functions
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    Chapter 5 IL-10 Detection in Murine B Cells: Pros and Cons of the Different Techniques
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    Chapter 6 TGF-β Detection and Measurement in Murine B Cells: Pros and Cons of the Different Techniques
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    Chapter 7 Characterization and Activity of Fas Ligand Producing CD5(+) B Cells.
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    Chapter 8 Utilization of a Lentiviral System for the Generation of B Cells with Regulatory Properties
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    Chapter 9 Ex Vivo Generation of Murine IL-10-Producing B Cells by Fusokines.
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    Chapter 10 Toll-like receptor ligation for the induction of regulatory B cells.
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    Chapter 11 The Generation of Regulatory B Cells by Helminth Parasites
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    Chapter 12 Use of cocultures for the study of cellular interactions influencing B cell regulatory functions.
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    Chapter 13 Regulatory B Cells in Experimental Mouse Models of Arthritis
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    Chapter 14 Regulatory B Cells in Mouse Models of Systemic Lupus Erythematosus (SLE)
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    Chapter 15 Regulatory B cells in allergic airways disease and asthma.
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    Chapter 16 Regulatory B Cells in Mouse Models of Intestinal Inflammation
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    Chapter 17 Regulatory B Cells in Experimental Autoimmune Encephalomyelitis (EAE).
  19. Altmetric Badge
    Chapter 18 Regulatory B cells, helminths, and multiple sclerosis.
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    Chapter 19 Generation and identification of tumor-evoked regulatory B cells.
Attention for Chapter 9: Ex Vivo Generation of Murine IL-10-Producing B Cells by Fusokines.
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Chapter title
Ex Vivo Generation of Murine IL-10-Producing B Cells by Fusokines.
Chapter number 9
Book title
Regulatory B Cells
Published in
Methods in molecular biology, July 2014
DOI 10.1007/978-1-4939-1161-5_9
Pubmed ID
25015277
Book ISBNs
978-1-4939-1160-8, 978-1-4939-1161-5
Authors

Tormo A, Deng J, Al-Chami E, Ziouani S, Rafei M, Aurélie Tormo, Jiusheng Deng, Edouard Al-Chami, Sonia Ziouani, Moutih Rafei

Abstract

Naïve B cells are crucial components of adaptive immunity. In addition to their capacity to produce immunoglobulins, a minor subset termed regulatory B cells or Bregs has been proven to modulate inflammation through the secretion of soluble mediators. The two main technical difficulties with their clinical use lie in their relatively low abundance in vivo and the scarcity of known methods for their ex vivo expansion. While studying the pharmacological properties of a novel bifunctional granulocyte macrophage-colony-stimulating factor (GM-CSF) and IL-15 fusion transgene (GIFT15) on unfractionated splenocytes in vitro, we observed that the GIFT15 fusokine had a remarkable and unprecedented effect on naïve B cells by converting them into suppressor cells of B-cell ontogeny (hereafter referred to as GIFT15 inducible (i)Bregs). Moreover, GIFT15 promoted iBreg proliferation. We present in this report a detailed protocol using the GIFT15 fusokine as a tool for the ex vivo generation of murine iBregs, which may serve as an immediate remedy to their abundance challenge in the clinic.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 50%
Student > Postgraduate 1 50%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 50%
Medicine and Dentistry 1 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2015.
All research outputs
#20,262,276
of 22,792,160 outputs
Outputs from Methods in molecular biology
#9,898
of 13,110 outputs
Outputs of similar age
#190,951
of 226,440 outputs
Outputs of similar age from Methods in molecular biology
#45
of 100 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,110 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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