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Regulatory B Cells

Overview of attention for book
Cover of 'Regulatory B Cells'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Purification and Immunophenotypic Characterization of Murine MZ and T2-MZP Cells
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    Chapter 2 Purification and Immune Phenotyping of B-1 Cells from Body Cavities of Mice
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    Chapter 3 Purification and Immunophenotypic Characterization of Murine B10 B Cells
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    Chapter 4 Purification and Immunophenotypic Characterization of Human B Cells with Regulatory Functions
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    Chapter 5 IL-10 Detection in Murine B Cells: Pros and Cons of the Different Techniques
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    Chapter 6 TGF-β Detection and Measurement in Murine B Cells: Pros and Cons of the Different Techniques
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    Chapter 7 Characterization and Activity of Fas Ligand Producing CD5(+) B Cells.
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    Chapter 8 Utilization of a Lentiviral System for the Generation of B Cells with Regulatory Properties
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    Chapter 9 Ex Vivo Generation of Murine IL-10-Producing B Cells by Fusokines.
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    Chapter 10 Toll-like receptor ligation for the induction of regulatory B cells.
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    Chapter 11 The Generation of Regulatory B Cells by Helminth Parasites
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    Chapter 12 Use of cocultures for the study of cellular interactions influencing B cell regulatory functions.
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    Chapter 13 Regulatory B Cells in Experimental Mouse Models of Arthritis
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    Chapter 14 Regulatory B Cells in Mouse Models of Systemic Lupus Erythematosus (SLE)
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    Chapter 15 Regulatory B cells in allergic airways disease and asthma.
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    Chapter 16 Regulatory B Cells in Mouse Models of Intestinal Inflammation
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    Chapter 17 Regulatory B Cells in Experimental Autoimmune Encephalomyelitis (EAE).
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    Chapter 18 Regulatory B cells, helminths, and multiple sclerosis.
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    Chapter 19 Generation and identification of tumor-evoked regulatory B cells.
Attention for Chapter 10: Toll-like receptor ligation for the induction of regulatory B cells.
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Chapter title
Toll-like receptor ligation for the induction of regulatory B cells.
Chapter number 10
Book title
Regulatory B Cells
Published in
Methods in molecular biology, July 2014
DOI 10.1007/978-1-4939-1161-5_10
Pubmed ID
25015278
Book ISBNs
978-1-4939-1160-8, 978-1-4939-1161-5
Authors

van der Vlugt LE, Haeberlein S, de Graaf W, Martha TE, Smits HH, Luciën E. P. M. van der Vlugt, Simone Haeberlein, Wouter de Graaf, Tyrill E. D. Martha, Hermelijn H. Smits

Abstract

Toll-like receptors (TLRs) are key components for the recognition of microorganisms, for the initiation of innate immunity, and for promoting adaptive immune responses. TLR signaling in B cells, in addition to B cell receptor or CD40 ligation, plays an important role in B cell differentiation and activation. In contrast, various infectious agents and/or TLR ligands can also prime B cells to induce tolerance and downregulate inflammatory reactions; those B cells are called regulatory B (Breg) cells and are characterized by a dominant IL-10 production. Several studies have suggested that Breg cells are impaired in patients with autoimmune diseases and allergic asthma. However, the role for TLR ligands in the induction of Breg cells as a potential therapy for some of these inflammatory diseases has not yet been investigated. Here, we provide detailed instructions on how to analyze and validate cytokine production in human and mouse B cells in response to various TLR ligands. Furthermore, we describe an assay to investigate the suppressive properties of TLR-induced B cells to confirm their regulatory B cell status.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 27%
Student > Doctoral Student 3 20%
Other 2 13%
Student > Bachelor 2 13%
Student > Master 1 7%
Other 0 0%
Unknown 3 20%
Readers by discipline Count As %
Immunology and Microbiology 4 27%
Medicine and Dentistry 3 20%
Mathematics 1 7%
Agricultural and Biological Sciences 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Other 0 0%
Unknown 5 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2015.
All research outputs
#20,262,276
of 22,792,160 outputs
Outputs from Methods in molecular biology
#9,898
of 13,110 outputs
Outputs of similar age
#190,951
of 226,440 outputs
Outputs of similar age from Methods in molecular biology
#45
of 100 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,110 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,440 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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