| Chapter title |
Mouse Models of Erythropoiesis and Associated Diseases
|
|---|---|
| Chapter number | 3 |
| Book title |
Erythropoiesis
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7428-3_3 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7427-6, 978-1-4939-7428-3
|
| Authors |
Matthew P. Parker, Kenneth R. Peterson |
| Abstract |
Animal models of erythropoiesis have been, and will continue to be, important tools for understanding molecular mechanisms underlying the development of this cell lineage and the pathophysiology associated with various human erythropoietic diseases. In this regard, the mouse is probably the most valuable animal model available to investigators. The physiology and short gestational period of mice make them ideal for studying developmental processes and modeling human diseases. These attributes, coupled with cutting-edge genetic tools such as transgenesis, gene knockouts, conditional gene knockouts, and genome editing, provide a significant resource to the research community to test a plethora of hypotheses. This review summarizes the mouse models available for studying a wide variety of erythroid-related questions, as well as the properties inherent in each one. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 16% |
| Researcher | 3 | 12% |
| Unspecified | 2 | 8% |
| Student > Doctoral Student | 2 | 8% |
| Student > Master | 2 | 8% |
| Other | 2 | 8% |
| Unknown | 10 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 28% |
| Unspecified | 2 | 8% |
| Medicine and Dentistry | 2 | 8% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 9 | 36% |