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Mendeley readers
Chapter title |
Studying Topoisomerase 1-Mediated Damage at Genomic Ribonucleotides
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Chapter number | 17 |
Book title |
DNA Topoisomerases
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Published in |
Methods in molecular biology, January 2018
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DOI | 10.1007/978-1-4939-7459-7_17 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7458-0, 978-1-4939-7459-7
|
Authors |
Jessica S. Williams, Thomas A. Kunkel |
Abstract |
Ribonucleotides incorporated into DNA by the DNA polymerases can be incised by Topoisomerase 1 (Top1) to initiate removal of ribonucleotides from the genome. This Top1-dependent ribonucleotide removal has been demonstrated to result in multiple forms of genome instability in yeast. Here, we describe both quantitative and qualitative assays to identify mutations and other forms of DNA damage resulting from Top1-cleavage at unrepaired genomic ribonucleotides. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 2 | 33% |
Student > Ph. D. Student | 2 | 33% |
Student > Bachelor | 1 | 17% |
Researcher | 1 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 67% |
Arts and Humanities | 1 | 17% |
Unknown | 1 | 17% |