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Mendeley readers
Chapter title |
Generation of Highly Selective MMP Antibody Inhibitors
|
---|---|
Chapter number | 26 |
Book title |
Proteases and Cancer
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Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7595-2_26 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7594-5, 978-1-4939-7595-2
|
Authors |
Dong Hyun Nam, Xin Ge |
Abstract |
Inhibiting individual MMPs of biomedical importance with high selectivity is critical for both fundamental research and therapy development. Here we describe the methods for discovery of inhibitory monoclonal antibodies from synthetic human antibody phage display libraries carrying convex paratopes encoded by long complementarity-determining region (CDR)-H3 segments. We demonstrate the application of this technique for isolation of highly specific and potent antibody inhibitors of human MMP-14. |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 2 | 17% |
Student > Bachelor | 1 | 8% |
Lecturer | 1 | 8% |
Researcher | 1 | 8% |
Student > Postgraduate | 1 | 8% |
Other | 0 | 0% |
Unknown | 6 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 17% |
Agricultural and Biological Sciences | 1 | 8% |
Unknown | 9 | 75% |