| Chapter title |
Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins
|
|---|---|
| Chapter number | 6 |
| Book title |
Updates on Clostridium difficile in Europe
|
| Published in |
Advances in experimental medicine and biology, January 2018
|
| DOI | 10.1007/978-3-319-72799-8_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-972798-1, 978-3-31-972799-8
|
| Authors |
Panagiotis Papatheodorou, Holger Barth, Nigel Minton, Klaus Aktories, Papatheodorou, Panagiotis, Barth, Holger, Minton, Nigel, Aktories, Klaus |
| Abstract |
Research on the human gut pathogen Clostridium difficile and its toxins has gained much attention, particularly as a consequence of the increasing threat to human health presented by emerging hypervirulent strains. Toxin A (TcdA) and B (TcdB) are the two major virulence determinants of C. difficile. Both are single-chain proteins with a similar multidomain architecture. Certain hypervirulent C. difficile strains also produce a third toxin, namely binary toxin CDT (Clostridium difficile transferase). As C. difficile toxins are the causative agents of C. difficile-associated diseases (CDAD), such as antibiotics-associated diarrhea and pseudomembranous colitis, considerable efforts have been expended to unravel their molecular mode-of-action and the cellular mechanisms responsible for their uptake. Notably, a high proportion of studies on C. difficile toxins were performed in European laboratories. In this chapter we will highlight important recent advances in C. difficile toxins research. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 14% |
| Student > Master | 3 | 8% |
| Other | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Unspecified | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 14 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Agricultural and Biological Sciences | 3 | 8% |
| Medicine and Dentistry | 3 | 8% |
| Unspecified | 2 | 6% |
| Immunology and Microbiology | 2 | 6% |
| Other | 3 | 8% |
| Unknown | 15 | 42% |