| Chapter title |
Elemental Analysis in Biological Matrices Using ICP-MS
|
|---|---|
| Chapter number | 4 |
| Book title |
Characterization of Nanoparticles Intended for Drug Delivery
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7352-1_4 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7350-7, 978-1-4939-7352-1
|
| Authors |
Matthew N. Hansen, Jeffrey D. Clogston, Hansen, Matthew N., Clogston, Jeffrey D. |
| Abstract |
The increasing exploration of metallic nanoparticles for use as cancer therapeutic agents necessitates a sensitive technique to track the clearance and distribution of the material once introduced into a living system. Inductively coupled plasma mass spectrometry (ICP-MS) provides a sensitive and selective tool for tracking the distribution of metal components from these nanotherapeutics. This chapter presents a standardized method for processing biological matrices, ensuring complete homogenization of tissues, and outlines the preparation of appropriate standards and controls. The method described herein utilized gold nanoparticle-treated samples; however, the method can easily be applied to the analysis of other metals. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 25% |
| Professor > Associate Professor | 1 | 25% |
| Student > Master | 1 | 25% |
| Unknown | 1 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 25% |
| Chemistry | 1 | 25% |
| Unknown | 2 | 50% |