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Computational Systems Biology

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Cover of 'Computational Systems Biology'

Table of Contents

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    Book Overview
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    Chapter 1 DNA Sequencing Data Analysis
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    Chapter 2 Transcriptome Sequencing: RNA-Seq
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    Chapter 3 Capture Hybridization of Long-Range DNA Fragments for High-Throughput Sequencing
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    Chapter 4 The Introduction and Clinical Application of Cell-Free Tumor DNA
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    Chapter 5 Bioinformatics Analysis for Cell-Free Tumor DNA Sequencing Data
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    Chapter 6 An Overview of Genome-Wide Association Studies
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    Chapter 7 Integrative Analysis of Omics Big Data
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    Chapter 8 The Reconstruction and Analysis of Gene Regulatory Networks
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    Chapter 9 Differential Coexpression Network Analysis for Gene Expression Data
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    Chapter 10 iSeq: Web-Based RNA-seq Data Analysis and Visualization
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    Chapter 11 Revisit of Machine Learning Supported Biological and Biomedical Studies
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    Chapter 12 Identifying Interactions Between Long Noncoding RNAs and Diseases Based on Computational Methods
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    Chapter 13 Survey of Computational Approaches for Prediction of DNA-Binding Residues on Protein Surfaces
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    Chapter 14 Computational Prediction of Protein O-GlcNAc Modification
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    Chapter 15 Machine Learning-Based Modeling of Drug Toxicity
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    Chapter 16 Metabolomics: A High-Throughput Platform for Metabolite Profile Exploration
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    Chapter 17 Single-Cell Protein Assays: A Review
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    Chapter 18 Data Analysis in Single-Cell Transcriptome Sequencing
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    Chapter 19 Applications of Single-Cell Sequencing for Multiomics
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    Chapter 20 Progress on Diagnosis of Tuberculous Meningitis
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    Chapter 21 Insights of Acute Lymphoblastic Leukemia with Development of Genomic Investigation
Attention for Chapter 13: Survey of Computational Approaches for Prediction of DNA-Binding Residues on Protein Surfaces
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Chapter title
Survey of Computational Approaches for Prediction of DNA-Binding Residues on Protein Surfaces
Chapter number 13
Book title
Computational Systems Biology
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7717-8_13
Pubmed ID
Book ISBNs
978-1-4939-7716-1, 978-1-4939-7717-8
Authors

Yi Xiong, Xiaolei Zhu, Hao Dai, Dong-Qing Wei

Abstract

The increasing number of protein structures with uncharacterized function necessitates the development of in silico prediction methods for functional annotations on proteins. In this chapter, different kinds of computational approaches are briefly introduced to predict DNA-binding residues on surface of DNA-binding proteins, and the merits and limitations of these methods are mainly discussed. This chapter focuses on the structure-based approaches and mainly discusses the framework of machine learning methods in application to DNA-binding prediction task.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 22%
Professor > Associate Professor 1 11%
Student > Bachelor 1 11%
Unknown 5 56%
Readers by discipline Count As %
Chemical Engineering 1 11%
Biochemistry, Genetics and Molecular Biology 1 11%
Chemistry 1 11%
Medicine and Dentistry 1 11%
Unknown 5 56%