Chapter title |
Metabolomics: A High-Throughput Platform for Metabolite Profile Exploration
|
---|---|
Chapter number | 16 |
Book title |
Computational Systems Biology
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7717-8_16 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7716-1, 978-1-4939-7717-8
|
Authors |
Jing Cheng, Wenxian Lan, Guangyong Zheng, Xianfu Gao |
Abstract |
Metabolomics aims to quantitatively measure small-molecule metabolites in biological samples, such as bodily fluids (e.g., urine, blood, and saliva), tissues, and breathe exhalation, which reflects metabolic responses of a living system to pathophysiological stimuli or genetic modification. In the past decade, metabolomics has made notable progresses in providing useful systematic insights into the underlying mechanisms and offering potential biomarkers of many diseases. Metabolomics is a complementary manner of genomics and transcriptomics, and bridges the gap between genotype and phenotype, which reflects the functional output of a biological system interplaying with environmental factors. Recently, the technology of metabolomics study has been developed quickly. This review will discuss the whole pipeline of metabolomics study, including experimental design, sample collection and preparation, sample detection and data analysis, as well as mechanism interpretation, which can help understand metabolic effects and metabolite function for living organism in system level. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 18% |
Student > Bachelor | 7 | 18% |
Student > Ph. D. Student | 5 | 13% |
Researcher | 3 | 8% |
Lecturer | 2 | 5% |
Other | 7 | 18% |
Unknown | 9 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 20% |
Biochemistry, Genetics and Molecular Biology | 8 | 20% |
Medicine and Dentistry | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Computer Science | 3 | 8% |
Other | 5 | 13% |
Unknown | 9 | 23% |