Chapter title |
Insights of Acute Lymphoblastic Leukemia with Development of Genomic Investigation
|
---|---|
Chapter number | 21 |
Book title |
Computational Systems Biology
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7717-8_21 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7716-1, 978-1-4939-7717-8
|
Authors |
Heng Xu, Yang Shu |
Abstract |
Treatment outcomes for acute lymphoblastic leukemia (ALL), especially pediatric ALL, have greatly improved due to the risk-adapted therapy. Combination of drug development, clinical practice, as well as basic genetic researches has brought the survival rate of ALL from less than 10% to more than 90% today, not only increasing the treatment efficacy but also limiting adverse drug reactions (ADRs). In this review, we summarized the landscape identification of ALL genetic alterations, which provided the opportunity to increase the survival rate and especially minimize the relapse risk of ALL, and highlighted the importance of the development of new technologies of genomic investigation for translational medicine. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 16% |
Student > Bachelor | 2 | 8% |
Lecturer | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 1 | 4% |
Other | 5 | 20% |
Unknown | 9 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 24% |
Medicine and Dentistry | 4 | 16% |
Agricultural and Biological Sciences | 2 | 8% |
Computer Science | 1 | 4% |
Social Sciences | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 40% |