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Chromothripsis

Overview of attention for book
Cover of 'Chromothripsis'

Table of Contents

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    Book Overview
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    Chapter 1 The Genomic Characteristics and Origin of Chromothripsis
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    Chapter 2 Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Events
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    Chapter 3 Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo
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    Chapter 4 Chromothripsis and the Macroevolution Theory
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    Chapter 5 Analysis of Chromothripsis by Combined FISH and Microarray Analysis
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    Chapter 6 Chromothripsis Detectable in Small Supernumerary Marker Chromosomes (sSMC) Using Fluorescence In Situ Hybridization (FISH)
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    Chapter 7 Identification of Chromothripsis in Biopsy Using SNP-Based Microarray
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    Chapter 8 Detection of Chromothripsis in Plants
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    Chapter 9 RNA-Seq Analysis to Detect Abnormal Fusion Transcripts Linked to Chromothripsis
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    Chapter 10 Experimental Determination of Checkpoint Adaptation by Mitotic Shake-Off and Microscopy
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    Chapter 11 A Role for Retrotransposons in Chromothripsis
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    Chapter 12 Generation of Micronuclei and Detection of Chromosome Pulverization
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    Chapter 13 Detection of Impaired DNA Replication and Repair in Micronuclei as Indicators of Genomic Instability and Chromothripsis
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    Chapter 14 Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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    Chapter 15 Genes, Proteins, and Biological Pathways Preventing Chromothripsis
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    Chapter 16 Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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    Chapter 17 Chromothripsis Detection and Characterization Using the CTLPScanner Web Server
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    Chapter 18 ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data
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    Chapter 19 Time-Lapse Imaging for the Detection of Chromosomal Abnormalities in Primate Preimplantation Embryos
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    Chapter 20 Correlative Live Imaging and Immunofluorescence for Analysis of Chromosome Segregation in Mouse Preimplantation Embryos
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    Chapter 21 Experimental Induction of Genome Chaos
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    Chapter 22 Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Change Analysis in Complex Chromosomal Rearrangements and Chromothripsis
Attention for Chapter 3: Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo
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Chapter title
Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo
Chapter number 3
Book title
Chromothripsis
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7780-2_3
Pubmed ID
29564816
Book ISBNs
978-1-4939-7779-6, 978-1-4939-7780-2
Authors

Franck Pellestor, Vincent Gatinois, Pellestor, Franck, Gatinois, Vincent

Abstract

The discovery of a new class of massive chromosomal rearrangement, baptized chromothripsis, in different cancers and congenital disorders has deeply modified our understanding on the genesis of complex genomic rearrangements. Several mechanisms, involving abortive apoptosis, telomere erosion, mitotic errors, micronuclei formation, and p53 inactivation, might cause chromothripsis. The remarkable point is that all these plausible mechanisms have been identified in the field of human reproduction as causal factors for reproductive failures and chromosomal abnormality genesis. Specific features of gametogenesis and early embryonic development may contribute to the emergence of chromothripsis. Multiple lines of evidence support the assumption that chromothripsis may arise more frequently than previously thought in both gametogenesis and early human embryogenesis.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 2%
Researcher 1 2%
Other 1 2%
Student > Master 1 2%
Unknown 40 91%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 5%
Medicine and Dentistry 1 2%
Unknown 41 93%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2018.
All research outputs
#16,904,913
of 24,858,211 outputs
Outputs from Methods in molecular biology
#5,825
of 13,964 outputs
Outputs of similar age
#282,310
of 453,891 outputs
Outputs of similar age from Methods in molecular biology
#594
of 1,485 outputs
Altmetric has tracked 24,858,211 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,964 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,891 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,485 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.

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