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CpG Islands

Overview of attention for book
Cover of 'CpG Islands'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 CpG Islands: A Historical Perspective
  3. Altmetric Badge
    Chapter 2 Biochemical Identification of Nonmethylated DNA by BioCAP-Seq
  4. Altmetric Badge
    Chapter 3 Prediction of CpG Islands as an Intrinsic Clustering Property Found in Many Eukaryotic DNA Sequences and Its Relation to DNA Methylation
  5. Altmetric Badge
    Chapter 4 CpG Islands in Cancer: Heads, Tails, and Sides
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    Chapter 5 Infinium DNA Methylation Microarrays on Formalin-Fixed, Paraffin-Embedded Samples
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    Chapter 6 The Use of Methylation-Sensitive Multiplex Ligation-Dependent Probe Amplification for Quantification of Imprinted Methylation
  8. Altmetric Badge
    Chapter 7 The Pancancer DNA Methylation Trackhub: A Window to The Cancer Genome Atlas Epigenomics Data
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    Chapter 8 Methylation-Sensitive Amplification Length Polymorphism (MS-AFLP) Microarrays for Epigenetic Analysis of Human Genomes
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    Chapter 9 Genome-Wide Profiling of DNA Methyltransferases in Mammalian Cells
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    Chapter 10 Experimental Design and Bioinformatic Analysis of DNA Methylation Data
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    Chapter 11 Assay for Transposase Accessible Chromatin (ATAC-Seq) to Chart the Open Chromatin Landscape of Human Pancreatic Islets
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    Chapter 12 Defining Regulatory Elements in the Human Genome Using Nucleosome Occupancy and Methylome Sequencing (NOMe-Seq)
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    Chapter 13 Genome-Wide Mapping of Protein–DNA Interactions on Nascent Chromatin
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    Chapter 14 Analysis of Chromatin Interactions Mediated by Specific Architectural Proteins in Drosophila Cells
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    Chapter 15 High-Throughput Single-Cell RNA Sequencing and Data Analysis
  17. Altmetric Badge
    Chapter 16 Functional Insulator Scanning of CpG Islands to Identify Regulatory Regions of Promoters Using CRISPR
  18. Altmetric Badge
    Chapter 17 An Application-Directed, Versatile DNA FISH Platform for Research and Diagnostics
Attention for Chapter 1: CpG Islands: A Historical Perspective
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Chapter title
CpG Islands: A Historical Perspective
Chapter number 1
Book title
CpG Islands
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7768-0_1
Pubmed ID
Book ISBNs
978-1-4939-7767-3, 978-1-4939-7768-0
Authors

Francisco Antequera, Adrian Bird

Abstract

The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecular biology in the last two decades of the twentieth century and to the development of high-throughput genomic technologies at the turn of the millennium. First identified as discrete G + C-rich regions of unmethylated DNA in several vertebrates, CGIs were soon found to display additional distinctive chromatin features from the rest of the genome in terms of accessibility and of the epigenetic modifications of their histones. These features, together with their colocalization with promoters and with origins of DNA replication in mammals, highlighted their relevance in the regulation of genomic processes. Recent approaches have shown with unprecedented detail the dynamics and diversity of the epigenetic landscape of CGIs during normal development and under pathological conditions. Also, comparative analyses across species have started revealing how CGIs evolve and contribute to the evolution of the vertebrate genome.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 33%
Researcher 5 24%
Student > Doctoral Student 3 14%
Student > Ph. D. Student 2 10%
Professor 1 5%
Other 2 10%
Unknown 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 48%
Biochemistry, Genetics and Molecular Biology 7 33%
Unspecified 1 5%
Medicine and Dentistry 1 5%
Unknown 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2018.
All research outputs
#7,682,469
of 12,745,229 outputs
Outputs from Methods in molecular biology
#2,518
of 8,372 outputs
Outputs of similar age
#151,354
of 273,184 outputs
Outputs of similar age from Methods in molecular biology
#6
of 7 outputs
Altmetric has tracked 12,745,229 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,372 research outputs from this source. They receive a mean Attention Score of 2.1. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,184 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.