| Chapter title |
The roles of cohesins in mitosis, meiosis, and human health and disease.
|
|---|---|
| Chapter number | 11 |
| Book title |
Cell Cycle Control
|
| Published in |
Methods in molecular biology, May 2014
|
| DOI | 10.1007/978-1-4939-0888-2_11 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-0887-5, 978-1-4939-0888-2
|
| Authors |
Brooker AS, Berkowitz KM, Amanda S. Brooker, Karen M. Berkowitz, Brooker, Amanda S., Berkowitz, Karen M. |
| Abstract |
Mitosis and meiosis are essential processes that occur during development. Throughout these processes, cohesion is required to keep the sister chromatids together until their separation at anaphase. Cohesion is created by multiprotein subunit complexes called cohesins. Although the subunits differ slightly in mitosis and meiosis, the canonical cohesin complex is composed of four subunits that are quite diverse. The cohesin complexes are also important for DNA repair, gene expression, development, and genome integrity. Here we provide an overview of the roles of cohesins during these different events as well as their roles in human health and disease, including the cohesinopathies. Although the exact roles and mechanisms of these proteins are still being elucidated, this review serves as a guide for the current knowledge of cohesins. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Colombia | 1 | <1% |
| Unknown | 186 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 40 | 21% |
| Student > Ph. D. Student | 36 | 19% |
| Student > Master | 20 | 11% |
| Researcher | 12 | 6% |
| Student > Doctoral Student | 8 | 4% |
| Other | 17 | 9% |
| Unknown | 55 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 80 | 43% |
| Agricultural and Biological Sciences | 23 | 12% |
| Medicine and Dentistry | 15 | 8% |
| Nursing and Health Professions | 2 | 1% |
| Immunology and Microbiology | 2 | 1% |
| Other | 8 | 4% |
| Unknown | 58 | 31% |