Chapter title |
The senescence arrest program and the cell cycle.
|
---|---|
Chapter number | 8 |
Book title |
Cell Cycle Control
|
Published in |
Methods in molecular biology, June 2014
|
DOI | 10.1007/978-1-4939-0888-2_8 |
Pubmed ID | |
Book ISBNs |
978-1-4939-0887-5, 978-1-4939-0888-2
|
Authors |
Bitto A, Crowe EP, Lerner C, Torres C, Sell C, Alessandro Bitto, Elizabeth P. Crowe, Chad Lerner, Claudio Torres, Christian Sell, Bitto, Alessandro, Crowe, Elizabeth P., Lerner, Chad, Torres, Claudio, Sell, Christian |
Abstract |
All living organisms are subject to progressive loss of function and damage to their tissues, a process known as aging. At the cellular level, the accumulation of damage to DNA, proteins, and organelles induces cellular senescence, a stress-response pathway that likely influences the aging process. Although the senescence arrest program was initially described in vitro, accumulating evidence suggests that this damage response program occurs in a variety of pathologic settings. This review discusses aspects of the senescence program, their interrelationships with damage arrest pathways, the cell cycle, and the impact of senescence in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 11% |
Unknown | 8 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 44% |
Student > Bachelor | 1 | 11% |
Other | 1 | 11% |
Student > Ph. D. Student | 1 | 11% |
Student > Postgraduate | 1 | 11% |
Other | 0 | 0% |
Unknown | 1 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 56% |
Medicine and Dentistry | 2 | 22% |
Computer Science | 1 | 11% |
Unknown | 1 | 11% |