Chapter title |
Drug Delivery Strategies of Chemical CDK Inhibitors
|
---|---|
Chapter number | 12 |
Book title |
Cyclin-Dependent Kinase (CDK) Inhibitors
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-2926-9_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2925-2, 978-1-4939-2926-9
|
Authors |
Daniel Alvira, Laura Mondragón |
Abstract |
The pharmacological use of new therapeutics is often limited by a safe and effective drug-delivery system. In this sense, new chemical CDK inhibitors are not an exception. Nanotechnology may be able to solve some of the main problems limiting cancer treatments such as more specific delivery of therapeutics and reduction of toxic secondary effects. It provides new delivery systems able to specifically target cancer cells and release the active molecules in a controlled fashion. Specifically, silica mesoporous supports (SMPS) have emerged as an alternative for more classical drug delivery systems based on polymers. In this chapter, we describe the synthesis of a SMPS containing the CDK inhibitor roscovitine as cargo molecule and the protocols for confirmation of the proper cargo release of the nanoparticles in cell culture employing cell viability, cellular internalization, and cell death induction studies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 2 | 17% |
Researcher | 2 | 17% |
Student > Bachelor | 2 | 17% |
Student > Master | 2 | 17% |
Other | 1 | 8% |
Other | 1 | 8% |
Unknown | 2 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 17% |
Chemistry | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Unknown | 3 | 25% |