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Teratogenicity Testing

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Cover of 'Teratogenicity Testing'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 An Overview of Teratology
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    Chapter 2 Teratology Study Guidelines: An Overview
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    Chapter 3 Biological Concerns on the Selection of Animal Models for Teratogenic Testing
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    Chapter 4 The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
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    Chapter 5 Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage
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    Chapter 6 Chick Embryonic Cardiomyocyte Micromass System for Assessing Developmental Cardiotoxicity of Drugs
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    Chapter 7 Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell
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    Chapter 8 Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs
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    Chapter 9 Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents
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    Chapter 10 Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology
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    Chapter 11 Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
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    Chapter 12 Effect of Teratogens on Development of Drosophila melanogaster
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    Chapter 13 Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
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    Chapter 14 Behavioral Teratogenesis in Drosophila melanogaster
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    Chapter 15 Evaluation of Teratogenicity of Pharmaceuticals Using FETAX
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    Chapter 16 Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays
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    Chapter 17 Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis
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    Chapter 18 Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development
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    Chapter 19 General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol
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    Chapter 20 Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio)
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    Chapter 21 Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer
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    Chapter 22 Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure
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    Chapter 23 Omics in Zebrafish Teratogenesis
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    Chapter 24 Proteomic Analysis of Zebrafish (Danio rerio) After Chemical Exposure
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    Chapter 25 Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio)
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    Chapter 26 Oxidative Stress Assessment in Zebrafish Larvae
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    Chapter 27 Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo
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    Chapter 28 Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus
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    Chapter 29 Histological and Histochemical Profile for Teratological Assessment in Mus musculus
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    Chapter 30 In Vivo Analysis of Apoptosis in Embryonic Hippocampus
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    Chapter 31 Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus
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    Chapter 32 Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse
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    Chapter 33 Methodology of Genotoxic and Teratogenic Studies in Rats
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    Chapter 34 Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos
Attention for Chapter 13: Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
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Chapter title
Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
Chapter number 13
Book title
Teratogenicity Testing
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7883-0_13
Pubmed ID
Book ISBNs
978-1-4939-7882-3, 978-1-4939-7883-0
Authors

Matheus C. Bianchini, José L. R. Portela, Robson L. Puntel, Daiana S. Ávila, Bianchini, Matheus C., Portela, José L. R., Puntel, Robson L., Ávila, Daiana S.

Abstract

Studies focusing on the teratogenicity of a series of new chemicals that are produced in a daily basis represent an important focus in toxicological/pharmaceutical research, particularly due to the risks arising from occupational exposure of the subjects. However, the complex mating procedures, scheduling of treatments, requirements for trained personnel, and elevated costs of traditional teratological assays with mammals hamper this type of assessments. Accordingly, the use of Drosophila melanogaster as a model for teratological studies has received considerable attention. Here some general protocols about Drosophila exposure-at different stages of their life cycle-to any chemical with putative teratological activity are presented. Importantly, some details about D. melanogaster embryonic, larval, pupal, or adult endpoints, that can be used to assess teratogenicity using flies as a model organism, are presented.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 25%
Student > Master 2 25%
Researcher 1 13%
Unspecified 1 13%
Unknown 2 25%
Readers by discipline Count As %
Unspecified 1 13%
Environmental Science 1 13%
Biochemistry, Genetics and Molecular Biology 1 13%
Engineering 1 13%
Unknown 4 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2018.
All research outputs
#19,015,492
of 23,577,654 outputs
Outputs from Methods in molecular biology
#8,199
of 13,410 outputs
Outputs of similar age
#333,752
of 444,928 outputs
Outputs of similar age from Methods in molecular biology
#942
of 1,483 outputs
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