Chapter title |
Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure
|
---|---|
Chapter number | 22 |
Book title |
Teratogenicity Testing
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7883-0_22 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7882-3, 978-1-4939-7883-0
|
Authors |
Ana M. Valentim, Valentim, Ana M. |
Abstract |
Apart from morphological, biochemical, and genetic alterations induced by teratogen compounds, there is an increase interest in characterizing behavioral alterations. Behavior is a sensitive parameter that can provide information regarding developmental disruptions noninvasively, as it is the result of brain processes. Behavioral disturbances interfere with animals' capacity to cope with the environment, having an impact on the organism's life. Hereby, it is proposed behavioral assays consisting on recording larvae in multiwell plates and video analysis with a proper software, allowing for teratogen screening of behavior. How to evaluate locomotor, anxiety-like and avoidance-like behaviors, and the integrity of sensory-motor functions and learning are discussed in this chapter. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 2 | 18% |
Student > Bachelor | 2 | 18% |
Professor | 1 | 9% |
Unknown | 6 | 55% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Neuroscience | 1 | 9% |
Engineering | 1 | 9% |
Unknown | 7 | 64% |