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Teratogenicity Testing

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Cover of 'Teratogenicity Testing'

Table of Contents

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    Book Overview
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    Chapter 1 An Overview of Teratology
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    Chapter 2 Teratology Study Guidelines: An Overview
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    Chapter 3 Biological Concerns on the Selection of Animal Models for Teratogenic Testing
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    Chapter 4 The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
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    Chapter 5 Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage
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    Chapter 6 Chick Embryonic Cardiomyocyte Micromass System for Assessing Developmental Cardiotoxicity of Drugs
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    Chapter 7 Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell
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    Chapter 8 Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs
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    Chapter 9 Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents
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    Chapter 10 Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology
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    Chapter 11 Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
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    Chapter 12 Effect of Teratogens on Development of Drosophila melanogaster
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    Chapter 13 Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
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    Chapter 14 Behavioral Teratogenesis in Drosophila melanogaster
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    Chapter 15 Evaluation of Teratogenicity of Pharmaceuticals Using FETAX
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    Chapter 16 Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays
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    Chapter 17 Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis
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    Chapter 18 Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development
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    Chapter 19 General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol
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    Chapter 20 Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio)
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    Chapter 21 Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer
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    Chapter 22 Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure
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    Chapter 23 Omics in Zebrafish Teratogenesis
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    Chapter 24 Proteomic Analysis of Zebrafish (Danio rerio) After Chemical Exposure
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    Chapter 25 Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio)
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    Chapter 26 Oxidative Stress Assessment in Zebrafish Larvae
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    Chapter 27 Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo
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    Chapter 28 Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus
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    Chapter 29 Histological and Histochemical Profile for Teratological Assessment in Mus musculus
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    Chapter 30 In Vivo Analysis of Apoptosis in Embryonic Hippocampus
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    Chapter 31 Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus
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    Chapter 32 Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse
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    Chapter 33 Methodology of Genotoxic and Teratogenic Studies in Rats
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    Chapter 34 Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos
Attention for Chapter 27: Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo
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Chapter title
Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo
Chapter number 27
Book title
Teratogenicity Testing
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7883-0_27
Pubmed ID
Book ISBNs
978-1-4939-7882-3, 978-1-4939-7883-0
Authors

Huseyin C. Yalcin, Yalcin, Huseyin C.

Abstract

Investigations of teratogenic effects of drugs generally involve testing the drug on animals and zebrafish embryo is a commonly used animal model for that purpose. In these studies, cardiovascular function of the animals needs to be evaluated to reveal the influence of exposure on the development of the cardiovascular system as well as on the growth of the whole animal. Here, relevant microscopy imaging and analysis protocols are described to calculate a variety of hemodynamic parameters for zebrafish embryos exposed to clinical drugs.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 23%
Student > Master 3 23%
Professor 1 8%
Student > Ph. D. Student 1 8%
Researcher 1 8%
Other 0 0%
Unknown 4 31%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 23%
Pharmacology, Toxicology and Pharmaceutical Science 2 15%
Agricultural and Biological Sciences 2 15%
Medicine and Dentistry 1 8%
Unknown 5 38%