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Stromal Immunology

Overview of attention for book
Attention for Chapter 7: Immunosuppression by Intestinal Stromal Cells
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2 tweeters

Citations

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Chapter title
Immunosuppression by Intestinal Stromal Cells
Chapter number 7
Book title
Stromal Immunology
Published in
Advances in experimental medicine and biology, January 2018
DOI 10.1007/978-3-319-78127-3_7
Pubmed ID
Book ISBNs
978-3-31-978125-9, 978-3-31-978127-3
Authors

Pinchuk, Iryna V, Powell, Don W, Iryna V. Pinchuk, Don W. Powell

Abstract

This chapter summarizes evidence that intestinal myofibroblasts, also called intestinal stromal cells, are derived in the adult from tissue mesenchymal stem cells under homeostasis and may be replenished by bone marrow mesenchymal stromal (stem) cells that are recruited after severe intestinal injury. A comparison of mechanism of immunosuppression or tolerance by adult intestinal stromal cells (myofibroblasts) is almost identical with those reported for mesenchymal stem cells of bone marrow origin. The list of suppression mechanisms includes PD-L1 and PD-L2/PD-1 immune checkpoint pathways, soluble mediator secretion, toll-like receptor-mediated tolerance, and augmentation of Treg cells. Further, both mesenchymal stem cells and intestinal stromal cells express an almost identical repertoire of CD molecules. Lastly, others have reported that isolate intestinal stromal cells are capable of differentiating into bone and less well into chondrocyte, but not into adipocytes, a finding that we have confirmed. These findings suggest that intestinal stromal cells (myofibroblasts) are partially differentiated adult, tissue-resident stem cells which are capable of exerting immune tolerance in the intestine. Their role in repair of inflammatory bowel disease and immune suppression in colorectal cancer needs further investigation.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 20%
Student > Ph. D. Student 2 20%
Student > Bachelor 1 10%
Student > Doctoral Student 1 10%
Student > Master 1 10%
Other 1 10%
Unknown 2 20%
Readers by discipline Count As %
Medicine and Dentistry 2 20%
Biochemistry, Genetics and Molecular Biology 2 20%
Agricultural and Biological Sciences 1 10%
Immunology and Microbiology 1 10%
Arts and Humanities 1 10%
Other 0 0%
Unknown 3 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2018.
All research outputs
#10,253,249
of 13,444,601 outputs
Outputs from Advances in experimental medicine and biology
#1,704
of 3,251 outputs
Outputs of similar age
#183,885
of 266,133 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 3 outputs
Altmetric has tracked 13,444,601 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,251 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,133 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.