| Chapter title |
Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL
|
|---|---|
| Chapter number | 15 |
| Book title |
Prokaryotic Systems Biology
|
| Published in |
Advances in experimental medicine and biology, January 2015
|
| DOI | 10.1007/978-3-319-23603-2_15 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-923602-5, 978-3-31-923603-2
|
| Authors |
Vaibhav Bhandari, Walid A. Houry, Bhandari, Vaibhav, Houry, Walid A. |
| Abstract |
In the dense cellular environment, protein misfolding and inter-molecular protein aggregation compete with protein folding. Chaperones associate with proteins to prevent misfolding and to assist in folding to the native state. In Escherichia coli, the chaperones trigger factor, DnaK/DnaJ/GrpE, and GroEL/ES are the major chaperones responsible for insuring proper de novo protein folding. With multitudes of proteins produced by the bacterium, the chaperones have to be selective for their substrates. Yet, chaperone selectivity cannot be too specific. Recent biochemical and high-throughput studies have provided important insights highlighting the strategies used by chaperones in maintaining proteostasis in the cell. Here, we discuss the substrate networks and cooperation among these protein folding chaperones. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 19% |
| Student > Doctoral Student | 2 | 10% |
| Student > Bachelor | 2 | 10% |
| Professor | 2 | 10% |
| Student > Ph. D. Student | 2 | 10% |
| Other | 5 | 24% |
| Unknown | 4 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 43% |
| Agricultural and Biological Sciences | 3 | 14% |
| Veterinary Science and Veterinary Medicine | 2 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Chemistry | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 5 | 24% |