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Proteostasis

Overview of attention for book
Cover of 'Proteostasis'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review.
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    Chapter 2 Proteostasis
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    Chapter 3 Proteostasis
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    Chapter 4 Immunodepletion and Immunopurification as Approaches for CSN Research.
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    Chapter 5 Proteostasis
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    Chapter 6 Strategies to Detect Endogenous Ubiquitination of a Target Mammalian Protein.
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    Chapter 7 In Vitro Ubiquitination: Self-Ubiquitination, Chain Formation, and Substrate Ubiquitination Assays.
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    Chapter 8 Isolation of the Ubiquitin-Proteome from Tumor Cell Lines and Primary Cells Using TUBEs.
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    Chapter 9 TUBEs-Mass Spectrometry for Identification and Analysis of the Ubiquitin-Proteome.
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    Chapter 10 Isolation of Ubiquitinated Proteins to High Purity from In Vivo Samples.
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    Chapter 11 Method for the Purification of Endogenous Unanchored Polyubiquitin Chains.
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    Chapter 12 Proteostasis
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    Chapter 13 Proteostasis
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    Chapter 14 Monitoring Ubiquitin-Coated Bacteria via Confocal Microscopy
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    Chapter 15 Detection and Analysis of Cell Cycle-Associated APC/C-Mediated Cellular Ubiquitylation In Vitro and In Vivo.
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    Chapter 16 Detection and Analysis of SUMOylation Substrates In Vitro and In Vivo.
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    Chapter 17 Detection of Protein-Protein Interactions and Posttranslational Modifications Using the Proximity Ligation Assay: Application to the Study of the SUMO Pathway.
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    Chapter 18 Dissecting SUMO Dynamics by Mass Spectrometry.
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    Chapter 19 Proteostasis
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    Chapter 20 Proteostasis
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    Chapter 21 Proteostasis
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    Chapter 22 Analysis of Protein Oligomerization by Electrophoresis.
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    Chapter 23 Blot-MS of Carbonylated Proteins: A Tool to Identify Oxidized Proteins.
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    Chapter 24 Proteostasis
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    Chapter 25 A Simple Protocol for High Efficiency Protein Isolation After RNA Isolation from Mouse Thyroid and Other Very Small Tissue Samples.
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    Chapter 26 Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future.
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    Chapter 27 Proteostasis
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    Chapter 28 Proteostasis
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    Chapter 29 Proteostasis
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    Chapter 30 Using AlphaScreen(®) to Identify Small-Molecule Inhibitors Targeting a Conserved Host-Pathogen Interaction.
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    Chapter 31 Proteostasis
Attention for Chapter 27: Proteostasis
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  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Chapter title
Proteostasis
Chapter number 27
Book title
Proteostasis
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3756-1_27
Pubmed ID
27613053
Book ISBNs
978-1-4939-3754-7, 978-1-4939-3756-1
Authors

McLellan, Lauren, Forder, Cassie, Cranston, Aaron, Harrigan, Jeanine, Jacq, Xavier, Lauren McLellan, Cassie Forder, Aaron Cranston, Jeanine Harrigan, Xavier Jacq

Editors

Rune Matthiesen

Abstract

The attachment of ubiquitin or ubiquitin-like modifiers to proteins is an important signal for the regulation of a variety of biological processes including the targeting of substrates for degradation, receptor internalization, regulation of gene expression, and DNA repair. Posttranslational modification of proteins by ubiquitin controls many cellular processes, and aberrant ubiquitylation can contribute to cancer, immunopathologies, and neurodegeneration. Thus, deubiquitylating enzymes (DUBs) that remove ubiquitin from proteins have become attractive therapeutic targets. Monitoring the activity of DUBs in cells or in tissues is critical for understanding the biological function of DUBs in particular pathways and is essential for determining the physiological specificity and potency of small-molecule DUB inhibitors. Here, we describe a method for the homogenization of animal tissues and incubation of tissue lysates with ubiquitin-based activity probes to monitor DUB activity in mouse tissues and target engagement following treatment of animals with small-molecule DUB inhibitors.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 2 29%
Researcher 2 29%
Student > Doctoral Student 1 14%
Student > Ph. D. Student 1 14%
Student > Bachelor 1 14%
Other 0 0%
Readers by discipline Count As %
Chemistry 2 29%
Agricultural and Biological Sciences 2 29%
Biochemistry, Genetics and Molecular Biology 1 14%
Neuroscience 1 14%
Immunology and Microbiology 1 14%
Other 0 0%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2016.
All research outputs
#14,860,134
of 22,888,307 outputs
Outputs from Methods in molecular biology
#4,701
of 13,132 outputs
Outputs of similar age
#219,031
of 393,716 outputs
Outputs of similar age from Methods in molecular biology
#469
of 1,471 outputs
Altmetric has tracked 22,888,307 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,132 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,716 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,471 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.

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