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Behavioral Neurobiology of Chronic Pain

Overview of attention for book
Attention for Chapter 285: Persistent Postsurgical Pain: Evidence from Breast Cancer Surgery, Groin Hernia Repair, and Lung Cancer Surgery.
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Chapter title
Persistent Postsurgical Pain: Evidence from Breast Cancer Surgery, Groin Hernia Repair, and Lung Cancer Surgery.
Chapter number 285
Book title
Behavioral Neurobiology of Chronic Pain
Published in
Current topics in behavioral neurosciences, February 2014
DOI 10.1007/7854_2014_285
Pubmed ID
Book ISBNs
978-3-66-245093-2, 978-3-66-245094-9

Mads Utke Werner, Joakim Mutahi Bischoff


Bradley K. Taylor, David P. Finn


The prevalences of severe persistent postsurgical pain (PPP) following breast cancer surgery (BCS), groin hernia repair (GHR), and lung cancer surgery (LCS) are 13, 2, and 4-12 %, respectively. Estimates indicate that 80,000 patients each year in the U.S.A. are affected by severe pain and debilitating impairment in the aftermath of BCS, GHR, and LCS. Data across the three surgical procedures indicate a 35-65 % decrease in prevalence of PPP at 4-6 years follow-up. However, this is outweighed by late-onset PPP, which appears following a pain-free interval. The consequences of PPP include severe impairments of physical, psychological, and socioeconomic aspects of life. The pathophysiology underlying PPP consists of a continuing inflammatory response, a neuropathic component, and/or a late reinstatement of postsurgical inflammatory pain. While the sensory profiles of PPP-patients and pain-free controls are comparable with hypofunction on the surgical side, this seems to be accentuated in PPP-patients. In BCS-patients and GHR-patients, the sensory profiles indicate inflammatory and neuropathic components with contribution of central sensitization. A number of surgical factors including increased duration of surgery, repeat surgery, more invasive surgical techniques, and intraoperative nerve lesion have been associated with PPP. One of the most consistent predictive factors for PPP is high intensity acute postsurgical pain, but also psychological factors including anxiety, catastrophizing trait, depression, and psychological vulnerability have been identified as significant predictors of PPP. The quest to identify improved surgical and anesthesiological techniques to prevent severe pain and functional impairment in patients after surgery continues.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 25%
Researcher 5 18%
Professor > Associate Professor 3 11%
Other 3 11%
Student > Ph. D. Student 3 11%
Other 6 21%
Unknown 1 4%
Readers by discipline Count As %
Medicine and Dentistry 14 50%
Psychology 4 14%
Neuroscience 2 7%
Nursing and Health Professions 2 7%
Social Sciences 1 4%
Other 3 11%
Unknown 2 7%