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Metagenomics

Overview of attention for book
Cover of 'Metagenomics'

Table of Contents

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    Book Overview
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    Chapter 1 Construction of Small-Insert and Large-Insert Metagenomic Libraries.
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    Chapter 2 Extraction of Total DNA and RNA from Marine Filter Samples and Generation of a cDNA as Universal Template for Marker Gene Studies.
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    Chapter 3 Construction and Screening of Marine Metagenomic Large Insert Libraries.
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    Chapter 4 Constructing and Screening a Metagenomic Library of a Cold and Alkaline Extreme Environment.
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    Chapter 5 DNA-, RNA-, and Protein-Based Stable-Isotope Probing for High-Throughput Biomarker Analysis of Active Microorganisms.
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    Chapter 6 Assessing Bacterial and Fungal Diversity in the Plant Endosphere.
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    Chapter 7 Shotgun Metagenomic Sequencing Analysis of Soft-Rot Enterobacteriaceae in Polymicrobial Communities.
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    Chapter 8 Cloning and Expression of Metagenomic DNA in Streptomyces lividans and Subsequent Fermentation for Optimized Production.
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    Chapter 9 Degradation Network Reconstruction Guided by Metagenomic Data.
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    Chapter 10 Novel Tools for the Functional Expression of Metagenomic DNA.
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    Chapter 11 A Microtiter Plate-Based Assay to Screen for Active and Stereoselective Hydrolytic Enzymes in Enzyme Libraries.
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    Chapter 12 Screening for Cellulase Encoding Clones in Metagenomic Libraries.
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    Chapter 13 Liquid Phase Multiplex High-Throughput Screening of Metagenomic Libraries Using p-Nitrophenyl-Linked Substrates for Accessory Lignocellulosic Enzymes.
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    Chapter 14 Screening Glycosyltransferases for Polyphenol Modifications.
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    Chapter 15 Methods for the Isolation of Genes Encoding Novel PHA Metabolism Enzymes from Complex Microbial Communities.
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    Chapter 16 Function-Based Metagenomic Library Screening and Heterologous Expression Strategy for Genes Encoding Phosphatase Activity.
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    Chapter 17 Activity-Based Screening of Metagenomic Libraries for Hydrogenase Enzymes.
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    Chapter 18 Screening for N-AHSL-Based-Signaling Interfering Enzymes.
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    Chapter 19 Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites.
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    Chapter 20 Erratum to: Cloning and Expression of Metagenomic DNA in Streptomyces lividans and Subsequent Fermentation for Optimized Production
Attention for Chapter 19: Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites.
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Chapter title
Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites.
Chapter number 19
Book title
Metagenomics
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6691-2_19
Pubmed ID
27900698
Book ISBNs
978-1-4939-6689-9, 978-1-4939-6691-2
Authors

F. Jerry Reen, Jose A. Gutiérrez-Barranquero, Fergal O’Gara

Editors

Wolfgang R. Streit, Rolf Daniel

Abstract

The advent of metagenomics based biodiscovery has provided researchers with previously unforeseen access to the rich tapestry of natural bioactivity that exists in the biosphere. Unhindered by the "culturable bottleneck" that has severely limited the translation of the genetic potential that undoubtedly exists in nature, metagenomics nonetheless requires ongoing technological developments to maximize its efficacy and applicability to the discovery of new chemical entities.Here we describe methodologies for the detection and isolation of quorum sensing (QS) signal molecules from metagenomics libraries. QS signals have already shown considerable potential for the activation and "awakening" of biosynthetic gene clusters, bridging the existing divide between the natural product repertoire and the natural biosynthetic biodiversity hinted at by nature's blueprint. The QS pipeline from high-throughput robotics to functional screening and hit isolation is detailed, highlighting the multidisciplinary nature of progressive biodiscovery programs.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 12%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 24%
Researcher 3 18%
Student > Bachelor 2 12%
Student > Ph. D. Student 1 6%
Librarian 1 6%
Other 2 12%
Unknown 4 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 35%
Biochemistry, Genetics and Molecular Biology 5 29%
Arts and Humanities 1 6%
Immunology and Microbiology 1 6%
Unknown 4 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2018.
All research outputs
#19,594,120
of 24,093,053 outputs
Outputs from Methods in molecular biology
#8,407
of 13,601 outputs
Outputs of similar age
#319,370
of 428,053 outputs
Outputs of similar age from Methods in molecular biology
#694
of 1,072 outputs
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So far Altmetric has tracked 13,601 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,072 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.

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