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Mendeley readers
Chapter title |
A Protocol for Generation of a Corticosterone Model of Psychiatric Disorders
|
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Chapter number | 24 |
Book title |
Proteomic Methods in Neuropsychiatric Research
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Published in |
Advances in experimental medicine and biology, March 2017
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DOI | 10.1007/978-3-319-52479-5_24 |
Pubmed ID | |
Book ISBNs |
978-3-31-952478-8, 978-3-31-952479-5
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Authors |
Paul C. Guest |
Editors |
Paul C. Guest |
Abstract |
Some patients with psychiatric disorders show hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. This may be due to an impaired feedback inhibition and can be seen through increased levels of circulating cortisol. Here a protocol is described to mimic this situation by subcutaneous implantation of corticosterone pellets in mice. We also present characterization of the model by looking at effects on neuronal proliferation in hippocampus, one of the main tissues known to be affected by HPA axis hyper-activation. Such tissues could be used in analyses by proteomic platforms. |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 83 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 1 | 1% |
Student > Master | 1 | 1% |
Unknown | 81 | 98% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 1 | 1% |
Unknown | 82 | 99% |