Chapter title |
What Have Proteomic Studies Taught Us About Novel Drug Targets in Autism?
|
---|---|
Chapter number | 3 |
Book title |
Proteomic Methods in Neuropsychiatric Research
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-3-319-52479-5_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-952478-8, 978-3-31-952479-5
|
Authors |
Paul C. Guest, Daniel Martins-de-Souza |
Editors |
Paul C. Guest |
Abstract |
Autism spectrum disorders (ASDs) are a heterogeneous group of conditions with complex behavioural phenotypes. Although ASDs show a high rate of heritability, genetic research alone has not provided a complete understanding of the underlying causes. Recent developments using imaging techniques and proteomic-based molecular profiling approaches have now begun to generate new insights into the underlying pathways affected in both the brain and the periphery in individuals with these conditions. Of potential high importance is the constant finding of gender-specific biomarker profiles in ASD patients. This suggests that there are either distinct adaptive mechanisms or different aetiological causes in male and female ASD patients. This chapter addresses the findings using these approaches with a view to identification of novel drug targets or new treatment strategies based on personalized medicine objectives. Eventually, this will lead to a better disease understanding of ASD at the physiological and molecular levels, which may facilitate novel drug discovery efforts in this challenging area of medicine. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Montenegro | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 22% |
Student > Ph. D. Student | 8 | 16% |
Researcher | 5 | 10% |
Student > Bachelor | 4 | 8% |
Professor | 4 | 8% |
Other | 4 | 8% |
Unknown | 13 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 11 | 22% |
Medicine and Dentistry | 9 | 18% |
Nursing and Health Professions | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 6 | 12% |
Unknown | 15 | 31% |