| Chapter title |
Cryoinjury Model for Tissue Injury and Repair in Bioengineered Human Striated Muscle
|
|---|---|
| Chapter number | 15 |
| Book title |
Skeletal Muscle Development
|
| Published in |
Methods in molecular biology, August 2017
|
| DOI | 10.1007/978-1-4939-7283-8_15 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7282-1, 978-1-4939-7283-8
|
| Authors |
Richard J. Mills, Holly K. Voges, Enzo R. Porrello, James E. Hudson, Mills, Richard J., Voges, Holly K., Porrello, Enzo R., Hudson, James E. |
| Abstract |
Regenerative medicine aims to replace injured tissues to restore normal physiological function. One possibility for achieving this goal is to activate or enhance endogenous regenerative pathways. Therefore, human tissue regeneration models may be useful tools for the discovery and development of novel regenerative therapeutics. In this chapter, we describe methods for the generation of three-dimensional bioengineered striated muscle in vitro and a cryoinjury model that can be applied to these tissues. This technique enables mechanistic in vitro analysis of the endogenous regenerative response of human striated muscle to injury, which is not possible using other in vivo approaches. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 30% |
| Researcher | 2 | 20% |
| Student > Ph. D. Student | 1 | 10% |
| Student > Master | 1 | 10% |
| Student > Postgraduate | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 2 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 30% |
| Environmental Science | 1 | 10% |
| Agricultural and Biological Sciences | 1 | 10% |
| Materials Science | 1 | 10% |
| Medicine and Dentistry | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 3 | 30% |