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Bacterial Multidrug Exporters

Overview of attention for book
Cover of 'Bacterial Multidrug Exporters'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 High-Resolution Crystallographic Analysis of AcrB Using Designed Ankyrin Repeat Proteins (DARPins)
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    Chapter 2 Crystallographic Analysis of Drug and Inhibitor-Binding Structure of RND-Type Multidrug Exporter AcrB in Physiologically Relevant Asymmetric Crystals
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    Chapter 3 Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors
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    Chapter 4 Crystallographic Analysis of the CusBA Heavy-Metal Efflux Complex of Escherichia coli
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    Chapter 5 Purification of AcrAB-TolC Multidrug Efflux Pump for Cryo-EM Analysis
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    Chapter 6 NMR Spectroscopy Approach to Study the Structure, Orientation, and Mechanism of the Multidrug Exporter EmrE
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    Chapter 7 Generation of Conformation-Specific Antibody Fragments for Crystallization of the Multidrug Resistance Transporter MdfA
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    Chapter 8 Biochemical Reconstitution and Characterization of Multicomponent Drug Efflux Transporters
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    Chapter 9 Covalently Linked Trimers of RND (Resistance-Nodulation-Division) Efflux Transporters to Study Their Mechanism of Action: Escherichia coli AcrB Multidrug Exporter as an Example
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    Chapter 10 Determining Ligand Path Through a Major Drug Transporter, AcrB, in Escherichia coli
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    Chapter 11 Molecular Modeling of Multidrug Properties of Resistance Nodulation Division (RND) Transporters
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    Chapter 12 A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria
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    Chapter 13 Regulation of the Expression of Bacterial Multidrug Exporters by Two-Component Signal Transduction Systems
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    Chapter 14 Study of the Expression of Bacterial Multidrug Efflux Pumps in Anaerobic Conditions
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    Chapter 15 Identification of a Staphylococcus aureus Efflux Pump Regulator Using a DNA–Protein Affinity Technique
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    Chapter 16 High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems
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    Chapter 17 Single-Molecule Analysis of Membrane Transporter Activity by Means of a Microsystem
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    Chapter 18 Large-Scale Femtoliter Droplet Array for Single Cell Efflux Assay of Bacteria
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    Chapter 19 Reconstitution and Transport Analysis of Eukaryotic Transporters in the Post-Genomic Era
Attention for Chapter 12: A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria
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  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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Chapter title
A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria
Chapter number 12
Book title
Bacterial Multidrug Exporters
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7454-2_12
Pubmed ID
29177833
Book ISBNs
978-1-4939-7452-8, 978-1-4939-7454-2
Authors

Liping Li, Sasha G. Tetu, Ian T. Paulsen, Karl A. Hassan

Abstract

The core genomes of most bacterial species include a large number of genes encoding putative efflux pumps. The functional roles of most of these pumps are unknown, however, they are often under tight regulatory control and expressed in response to their substrates. Therefore, one way to identify pumps that function in antimicrobial resistance is to examine the transcriptional responses of efflux pump genes to antimicrobial shock. By conducting complete transcriptomic experiments following antimicrobial shock treatments, it may be possible to identify novel drug efflux pumps encoded in bacterial genomes. In this chapter we describe a complete workflow for conducting transcriptomic analyses by RNA sequencing, to determine transcriptional changes in bacteria responding to antimicrobials.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 31%
Student > Ph. D. Student 4 25%
Student > Master 2 13%
Student > Doctoral Student 1 6%
Student > Bachelor 1 6%
Other 1 6%
Unknown 2 13%
Readers by discipline Count As %
Immunology and Microbiology 5 31%
Agricultural and Biological Sciences 4 25%
Biochemistry, Genetics and Molecular Biology 3 19%
Computer Science 1 6%
Medicine and Dentistry 1 6%
Other 0 0%
Unknown 2 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2018.
All research outputs
#14,368,528
of 23,009,818 outputs
Outputs from Methods in molecular biology
#4,225
of 13,157 outputs
Outputs of similar age
#240,431
of 442,295 outputs
Outputs of similar age from Methods in molecular biology
#432
of 1,498 outputs
Altmetric has tracked 23,009,818 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,157 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,295 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,498 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.

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