Applications of Peptide retention time in proteomic data analysis.
Urine Proteomics in Kidney Disease Biomarker Discovery
Advances in experimental medicine and biology, January 2015
In proteomic studies, liquid chromatography is commonly used to separate peptide mixtures prior to mass spectrometry (MS) detection. As an independent dimension of information from the information provided by the MS, peptide retention time information has been proven to be able to aid proteomic data analysis in many aspects. So far, some popular software has offered options for this information for MS data acquisition and analysis. This chapter is a brief review of current methodologies of retention time prediction and application in proteomic analysis.
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