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Urine Proteomics in Kidney Disease Biomarker Discovery

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Cover of 'Urine Proteomics in Kidney Disease Biomarker Discovery'

Table of Contents

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    Book Overview
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    Chapter 1 Urine Is a Better Biomarker Source Than Blood Especially for Kidney Diseases
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    Chapter 2 Urine Reflection of Changes in Blood
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    Chapter 3 Urimem Facilitates Kidney Disease Biomarker Research
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    Chapter 4 Human urine proteome: a powerful source for clinical research.
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    Chapter 5 Exosomes in Urine Biomarker Discovery
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    Chapter 6 Urinary Proteins with Post-translational Modifications.
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    Chapter 7 Applications of Peptide retention time in proteomic data analysis.
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    Chapter 8 Urine Sample Preparation in 96-well Filter Plates to Characterize Inflammatory and Infectious Diseases of the Urinary Tract.
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    Chapter 9 Variations of human urinary proteome.
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    Chapter 10 Evolution of the urinary proteome during human renal development and maturation.
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    Chapter 11 Hormone-dependent changes in female urinary proteome.
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    Chapter 12 Effects of exercise on the urinary proteome.
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    Chapter 13 Effects of diuretics on urinary proteins.
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    Chapter 14 Applications of urinary proteomics in renal disease research using animal models.
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    Chapter 15 The application of urinary proteomics for the detection of biomarkers of kidney diseases.
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    Chapter 16 Dynamic changes of urinary proteins in focal segmental glomerulosclerosis model.
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    Chapter 17 Using isolated rat kidney to discover kidney origin biomarkers in urine.
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    Chapter 18 Comparing plasma and urinary proteomes to understand kidney function.
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    Chapter 19 Urinary protein biomarker database: a useful tool for biomarker discovery.
Attention for Chapter 14: Applications of urinary proteomics in renal disease research using animal models.
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Chapter title
Applications of urinary proteomics in renal disease research using animal models.
Chapter number 14
Book title
Urine Proteomics in Kidney Disease Biomarker Discovery
Published in
Advances in experimental medicine and biology, November 2014
DOI 10.1007/978-94-017-9523-4_14
Pubmed ID
Book ISBNs
978-9-40-179522-7, 978-9-40-179523-4
Authors

Lv Y, Cai G, Chen X, Yang Lv, Guangyan Cai, Xiangmei Chen

Abstract

Animal models of renal disease are essential tools in research on kidney disease and have provided valuable insights into pathogenesis. Use of animal models minimises inter-individual differences, allows specific pathological changes to be examined, and facilitates collection of tissue samples. Thus, mechanistic research and identification of biomarkers are possible. Various animal models manifesting specific pathological lesions can be used to investigate acute or chronic kidney disease (CKD). Urine, a terminal metabolic product, is produced via glomerular filtration, reabsorption, and excretion in the tubular and collecting ducts, reflecting the functions of glomeruli or tubular tissue stimulated in various ways or subject to disease. Almost 70 % of urinary proteins originate from the kidney (the other 30 % come from plasma), and urinary sampling is important to noninvasively detect renal disease. Proteomics is powerful when used to screen urine components. Increasingly, urine proteomics is used to explore the pathogenesis of kidney disease in animals and to identify novel biomarkers of renal disease. In this section, we will introduce the field of urinary proteomics as applied in different models of animal renal disease and the valuable role played by proteomics in noninvasive diagnosis and rational treatment of human renal disease.

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