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Urine Proteomics in Kidney Disease Biomarker Discovery

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Cover of 'Urine Proteomics in Kidney Disease Biomarker Discovery'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Urine Is a Better Biomarker Source Than Blood Especially for Kidney Diseases
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    Chapter 2 Urine Reflection of Changes in Blood
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    Chapter 3 Urimem Facilitates Kidney Disease Biomarker Research
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    Chapter 4 Human urine proteome: a powerful source for clinical research.
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    Chapter 5 Exosomes in Urine Biomarker Discovery
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    Chapter 6 Urinary Proteins with Post-translational Modifications.
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    Chapter 7 Applications of Peptide retention time in proteomic data analysis.
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    Chapter 8 Urine Sample Preparation in 96-well Filter Plates to Characterize Inflammatory and Infectious Diseases of the Urinary Tract.
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    Chapter 9 Variations of human urinary proteome.
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    Chapter 10 Evolution of the urinary proteome during human renal development and maturation.
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    Chapter 11 Hormone-dependent changes in female urinary proteome.
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    Chapter 12 Effects of exercise on the urinary proteome.
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    Chapter 13 Effects of diuretics on urinary proteins.
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    Chapter 14 Applications of urinary proteomics in renal disease research using animal models.
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    Chapter 15 The application of urinary proteomics for the detection of biomarkers of kidney diseases.
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    Chapter 16 Dynamic changes of urinary proteins in focal segmental glomerulosclerosis model.
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    Chapter 17 Using isolated rat kidney to discover kidney origin biomarkers in urine.
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    Chapter 18 Comparing plasma and urinary proteomes to understand kidney function.
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    Chapter 19 Urinary protein biomarker database: a useful tool for biomarker discovery.
Attention for Chapter 10: Evolution of the urinary proteome during human renal development and maturation.
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Chapter title
Evolution of the urinary proteome during human renal development and maturation.
Chapter number 10
Book title
Urine Proteomics in Kidney Disease Biomarker Discovery
Published in
Advances in experimental medicine and biology, November 2014
DOI 10.1007/978-94-017-9523-4_10
Pubmed ID
Book ISBNs
978-9-40-179522-7, 978-9-40-179523-4
Authors

Wang Z, Li M, Zi Wang, Mingxi Li

Abstract

Renal development process in human is divided into 3 successive stages: pronephros, mesonephros, and metanephros. The tubules continue to mature for 1-2 year after birth. Research of urinary proteome during human renal development is still lacking. Most urine proteome studies focus on postnatal renal maturation period. A comparison between full-term infant and adult urinary protein pattern identified 648 infant-enriched protein spots, of which most were involved in cellular turnover and metabolism. The study of preterm infant urinary proteome compared with term infants suggests elevated IGFBP-1, IGFBP-2, and IGFBP-6, monocyte chemotactic protein-1, CD14, and sialic acid-binding Ig-like lectin 5 during nephrogenesis. Research in several congenital kidney and urinary tract anomalies, ureteropelvic junction obstruction and autosomal dominant polycystic kidney disease, has discovered novel biomarkers, which may help to imply the mechanisms underlying inherited disorders. Future exploration of urinary proteome evolution during renal maturation is needed and will help to find novel biomarkers specially suiting pediatric renal diseases.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 19%
Student > Master 4 19%
Researcher 2 10%
Student > Doctoral Student 2 10%
Other 2 10%
Other 3 14%
Unknown 4 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 43%
Medicine and Dentistry 2 10%
Mathematics 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Environmental Science 1 5%
Other 0 0%
Unknown 7 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2015.
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#4,089,221
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Outputs from Advances in experimental medicine and biology
#1,073
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Outputs of similar age
#126,594
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Outputs of similar age from Advances in experimental medicine and biology
#9
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