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Urine Proteomics in Kidney Disease Biomarker Discovery

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Cover of 'Urine Proteomics in Kidney Disease Biomarker Discovery'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Urine Is a Better Biomarker Source Than Blood Especially for Kidney Diseases
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    Chapter 2 Urine Reflection of Changes in Blood
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    Chapter 3 Urimem Facilitates Kidney Disease Biomarker Research
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    Chapter 4 Human urine proteome: a powerful source for clinical research.
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    Chapter 5 Exosomes in Urine Biomarker Discovery
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    Chapter 6 Urinary Proteins with Post-translational Modifications.
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    Chapter 7 Applications of Peptide retention time in proteomic data analysis.
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    Chapter 8 Urine Sample Preparation in 96-well Filter Plates to Characterize Inflammatory and Infectious Diseases of the Urinary Tract.
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    Chapter 9 Variations of human urinary proteome.
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    Chapter 10 Evolution of the urinary proteome during human renal development and maturation.
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    Chapter 11 Hormone-dependent changes in female urinary proteome.
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    Chapter 12 Effects of exercise on the urinary proteome.
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    Chapter 13 Effects of diuretics on urinary proteins.
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    Chapter 14 Applications of urinary proteomics in renal disease research using animal models.
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    Chapter 15 The application of urinary proteomics for the detection of biomarkers of kidney diseases.
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    Chapter 16 Dynamic changes of urinary proteins in focal segmental glomerulosclerosis model.
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    Chapter 17 Using isolated rat kidney to discover kidney origin biomarkers in urine.
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    Chapter 18 Comparing plasma and urinary proteomes to understand kidney function.
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    Chapter 19 Urinary protein biomarker database: a useful tool for biomarker discovery.
Attention for Chapter 13: Effects of diuretics on urinary proteins.
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Chapter title
Effects of diuretics on urinary proteins.
Chapter number 13
Book title
Urine Proteomics in Kidney Disease Biomarker Discovery
Published in
Advances in experimental medicine and biology, November 2014
DOI 10.1007/978-94-017-9523-4_13
Pubmed ID
Book ISBNs
978-9-40-179522-7, 978-9-40-179523-4
Authors

Li X, Xundou Li

Abstract

Biomarker is the measurable change associated with a physiological or pathophysiological process. Unlike blood which has mechanisms to keep the internal environment homeostatic, urine is more likely to reflect changes of the body. As a result, urine is likely to be a better biomarker source than blood. However, since the urinary proteome is affected by many factors, including diuretics, careful evaluation of those effects is necessary if urinary proteomics is used for biomarker discovery. The human orthologs of most of these 14 proteins affected are stable in the healthy human urinary proteome, and 10 of them are reported as disease biomarkers. Thus, our results suggest that the effects of diuretics deserve more attention in future urinary protein biomarker studies. Moreover, the distinct effects of diuretics on the urinary proteome may provide clues to the mechanisms of diuretics.

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Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 33%
Professor 1 33%
Unknown 1 33%
Readers by discipline Count As %
Medicine and Dentistry 1 33%
Unknown 2 67%

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