Urinary Proteins with Post-translational Modifications.
Urine Proteomics in Kidney Disease Biomarker Discovery
Advances in experimental medicine and biology, November 2014
Liu L, Liu X, Liu Liu, Xuejiao Liu
Research on the human urine proteome may lay the foundation for the discovery of relevant disease biomarkers. Posttranslational modifications (PTMs) have important effects on the functions of protein biomarkers. Identifying PTMs without enrichment adds no extra steps to conventional identification procedures for urine proteomics. The only difference is that this method requires software that can conduct unrestrictive identifications of PTMs. These PTMs include methylation, dehydration, oxidation, hydroxylation, phosphorylation, or dihydroxylation. These data are useful reference for PTM biomarker discovery in the future.
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