Hormone-dependent changes in female urinary proteome.
Urine Proteomics in Kidney Disease Biomarker Discovery
Advances in experimental medicine and biology, November 2014
Castagna A, Channavajjhala SK, Pizzolo F, Olivieri O, Annalisa Castagna, Sarath Kiran Channavajjhala, Francesca Pizzolo, Oliviero Olivieri
Human urine represents a good source for proteomic research for clinically related studies as it can be collected and processed easily and can give information about kidney-related mechanisms. Little is known about the urinary proteomic changes resulting from physiological (normal), pathological, or environmental variations, and there are few reports on hormone-related modifications of urine proteome. In our study, we highlighted the variations of urinary proteins associated with menstrual cycle or estro-progestin pill in females. We also described an association between some urinary proteins and the renin-angiotensin-aldosterone system, which might help to improve the understanding of physiological and pathological processes when a gender-specific pattern such as the menopause-related hypertension or eclampsia is evident. We therefore support the usefulness of urinary proteomics as a valuable tool for clinically related study as it can provide information on candidate biomarkers which, in turn, need to be confirmed by multiple approaches before the use in a clinical setting.
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